ArticleWorld journal of gastroenterology2003
Role of mitochondrial dysfunction in hydrogen peroxide-induced apoptosis of intestinal epithelial cells.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Carpaine Promotes Proliferation and Repair of H9c2 Cardiomyocytes after Oxidative Insults.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Vitamin D Modulation of Mitochondrial Oxidative Metabolism and mTOR Enforces Stress Adaptations and Anticancer Responses.JBMR plus · 2022Article
- Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models.Stem cell research & therapy · 2014Article
- Oxidative stress-induced intestinal epithelial cell apoptosis is mediated by p38 MAPK.Biochemical and biophysical research communications · 2006Article
- Apoptosis of human colon carcinoma HT-29 cells induced by ceramide.World journal of gastroenterology · 2006Article
- Signal transduction pathways involved in oxidative stress-induced intestinal epithelial cell apoptosis.Pediatric research · 2005Article
- Effects of hydroxyapatite nanoparticles on proliferation and apoptosis of human hepatoma BEL-7402 cells.World journal of gastroenterology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the role of mitochondrial dysfunction in hydrogen peroxide-induced apoptosis of intestinal epithelial cells.
methodsHydrogen peroxide-induced apoptosis of human intestinal epithelial cell line SW-480 was established. Cell apoptosis was determined by Annexin-V and PI double-stained flow cytometry and DNA gel electrophoresis. Morphological changes were examined with light and electron microscopy. For other observations, mitochondrial function, cytochrome c release, mitochondrial translocation and membrane potential were determined simultaneously.
resultsPercentage of apoptotic cells induced with 400 micro mol/L hydrogen peroxide increased significantly at l h or 3 h after stimulation and recovered rapidly. Meanwhile percentage of apoptotic cells induced with 4 mmol/L hydrogen peroxide increased with time. In accordance with these changes, we observed decreased mitochondrial function in 400 micro mol/L H2O2-stimualted cells at 1 h or 3 h and in 4 mmol/L H2O2-stimualted cells at times examined. Correspondingly, swelling cristae and vacuole-like mitochondria were noted. Release of cytochrome c, decreased mitochondrial membrane potential and mitochondrial translocation were also found to be the early signs of apoptosis.
conclusionDysfunctional mitochondria play a role in the apoptosis of SW-480 cell line induced by hydrogen peroxide.
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Registered trials
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