ArticleWorld journal of gastroenterology2003
A selective tropism of transfused oval cells for liver.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis.Molecular metabolism · 2018Article
- Dysregulation of Bmi1 promotes malignant transformation of hepatic progenitor cells.Oncogenesis · 2016Article
- Selective tropism of liver stem cells to hepatocellular carcinoma in vivo.World journal of gastroenterology · 2007Article
- Influence of serum from liver-damaged rats on differentiation tendency of bone marrow-derived stem cells.World journal of gastroenterology · 2004Article
- Characterization and enrichment of hepatic progenitor cells in adult rat liver.World journal of gastroenterology · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo explore the biological behaviors of hepatic oval cells after transfused into the circulation of experimental animals.
methodsOval cells from male SD rat were transfused into the circulation of a female rat which were treated by a 2-AAF/CCl(4) program, through caudal vein. Sex-determining gene sry which located on Y chromosome was examined by PCR and in situ hybridization technique in liver, kidney and spleen of the experimental animals, respectively.
resultsThe results of the cell-transplant experiment showed that the sry gene was detectable only in the liver but not in spleen and kidney of the experimental rats, and no signals could be detected in the control animals. It can be also morphologically proved that some exogenous cells had migrated into the parenchyma of the liver and settled there.
conclusionThe result means that there are exogenous cells located in the liver of the experimental animal and the localization is specific to the liver. This indicates that some "signal molecules" must exist in the circulation of the rats treated by 2-AAF/CCl(4). These "signal molecules" might play an important role in specific localization and differentiation of transfused oval cells.
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