ArticlePediatric cardiology
Flow in the early embryonic human heart: a numerical study.
Article in Pediatric cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Hemodynamic and Structural Comparison of Human Fetal Heart Development Between Normally Growing and Hypoplastic Left Heart Syndrome-Diagnosed Hearts.Frontiers in physiology · 2022Article
- Vortex Dynamics in Trabeculated Embryonic Ventricles.Journal of cardiovascular development and disease · 2019Article
- Fluid dynamics in heart development: effects of hematocrit and trabeculation.Mathematical medicine and biology : a journal of the IMA · 2018Article
- Left atrial ligation alters intracardiac flow patterns and the biomechanical landscape in the chick embryo.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Biomechanics of early cardiac development.Biomechanics and modeling in mechanobiology · 2012Article
- Computational fluid dynamics of developing avian outflow tract heart valves.Annals of biomedical engineering · 2012Article
- Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts.Computers & structures · 2011Article
- Hemodynamic patterning of the avian atrioventricular valve.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- The development of the heart and microcirculation: role of shear stress.Medical & biological engineering & computing · 2008Article
- In vitro hemodynamic investigation of the embryonic aortic arch at late gestation.Journal of biomechanics · 2008Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Computational fluid dynamic (CFD) experimentation provides a unique medium for detailed examination of flow through complex embryonic heart structures. The purpose of this investigation was to demonstrate that streaming blood flow patterns exist in the early embryonic heart and that fluid surface stresses change significantly with anomalous alterations in fetal heart lumen shape. Stages 10 and 11 early human embryo hearts were digitized as calibrated two-dimensional (2D) cross-sectional sequential images. A 3D surface was constructed from the stacking of these 2D images. CFD flow solutions were obtained (steady and pulsatile flow). Particle traces were placed in the inlet and outlet portions of these two stages. Sections of the embryonic heart were artificially reshaped. CFD flow solutions were obtained and surface stress changes analyzed. Streaming was shown to exist, with particles released on one or the other side of the cardiac lumen tending not to cross over and mix with particles released from the opposite side of the cardiac lumen. Shear stress changes (stage 10) occur in the altered lumens. Streaming exists in steady and pulsatile flow scenarios in the embryonic heart models. There are differences in local shear stress distributions with surface shape anomalies of the fetal heart lumen. These observations may help shed light on the potential role of fluid dynamic factors in determining patterns of abnormal heart development.
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