ArticlePflugers Archiv : European journal of physiology2003
Variability in fibre properties in paralysed human quadriceps muscles and effects of training.
Article in Pflugers Archiv : European journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Characteristics of fast voluntary and electrically evoked isometric knee extensions during 56 days of bed rest with and without exercise countermeasure.European journal of applied physiology · 2008Trial
- Delayed muscle fatigue during electrical stimulation of the proximal nerve using asymmetric random high-frequency carrier pulse cluster.Journal of neuroengineering and rehabilitation · 2025Article
- GsMTx-4 combined with exercise improves skeletal muscle structure and motor function in rats with spinal cord injury.PloS one · 2025Article
- Practical approaches of PULSE Racing in training their athlete for the Cybathlon Global Edition Functional Electrical Stimulation bike race: a case report.Journal of neuroengineering and rehabilitation · 2023Article
- Approach to Small Animal Neurorehabilitation by Locomotor Training: An Update.Animals : an open access journal from MDPI · 2022Review
- User-centered design and spatially-distributed sequential electrical stimulation in cycling for individuals with paraplegia.Journal of neuroengineering and rehabilitation · 2022Article
- Reducing muscle fatigue during transcutaneous neuromuscular electrical stimulation by spatially and sequentially distributing electrical stimulation sources.European journal of applied physiology · 2014Article
- Recovery of neuronal and network excitability after spinal cord injury and implications for spasticity.Frontiers in integrative neuroscience · 2014Review
- A biomechanical analysis of exercise in standing, supine, and seated positions: Implications for individuals with spinal cord injury.The journal of spinal cord medicine · 2012Article
- Role of alpha-actinin-3 in contractile properties of human single muscle fibers: a case series study in paraplegics.PloS one · 2012Article
- A proteomics analysis of the effects of chronic hemiparetic stroke on troponin T expression in human vastus lateralis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2009Article
- Recovery of control of posture and locomotion after a spinal cord injury: solutions staring us in the face.Progress in brain research · 2009Review
- Effects of stimulation frequency versus pulse duration modulation on muscle fatigue.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2008Article
- Leg joint power output during progressive resistance FES-LCE cycling in SCI subjects: developing an index of fatigue.Journal of neuroengineering and rehabilitation · 2008Article
- Skeletal muscle changes after hemiparetic stroke and potential beneficial effects of exercise intervention strategies.Journal of rehabilitation research and development · 2008Review
- Human genome comparison of paretic and nonparetic vastus lateralis muscle in patients with hemiparetic stroke.Journal of rehabilitation research and development · 2008Article
- Muscle and bone plasticity after spinal cord injury: review of adaptations to disuse and to electrical muscle stimulation.Journal of rehabilitation research and development · 2008Review
- Low-frequency fatigue in individuals with spinal cord injury.The journal of spinal cord medicine · 2007Article
- TGF-beta1 favors the development of fast type identity during soleus muscle regeneration.Journal of muscle research and cell motility · 2006Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A spinal cord injury usually leads to an increase in contractile speed and fatigability of the paralysed quadriceps muscles, which is probably due to an increased expression of fast myosin heavy chain (MHC) isoforms and reduced oxidative capacity. Sometimes, however, fatigue resistance is maintained in these muscles and also contractile speed is slower than expected. To obtain a better understanding of the diversity of these quadriceps muscles and to determine the effects of training on characteristics of paralysed muscles, fibre characteristics and whole muscle function were assessed in six subjects with spinal cord lesions before and after a 12-week period of daily low-frequency electrical stimulation. Relatively high levels of MHC type I were found in three subjects and this corresponded with a high degree of fusion in 10-Hz force responses (r=0.88). Fatigability was related to the activity of succinate dehydrogenase (SDH) (r=0.79). Furthermore, some differentiation between fibre types in terms of metabolic properties were present, with type I fibres expressing the highest levels of SDH and lowest levels of alpha-glycerophosphate dehydrogenase. After training, SDH activity increased by 76+/-26% but fibre diameter and MHC expression remained unchanged. The results indicate that expression of contractile proteins and metabolic properties seem to underlie the relatively normal functional muscle characteristics observed in some paralysed muscles. Furthermore, training-induced changes in fatigue resistance seem to arise, in part, from an improved oxidative capacity.
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