ArticleMolecular biology of the cell2003
Analysis of Na+,K+-ATPase motion and incorporation into the plasma membrane in response to G protein-coupled receptor signals in living cells.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- Triclosan disrupts immune cell function by depressing CaToxicology and applied pharmacology · 2020Article
- Influenza A Virus Infection Induces Apical Redistribution of NaAmerican journal of respiratory cell and molecular biology · 2019Article
- Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Ubiquitin-proteasome signaling in lung injury.Translational research : the journal of laboratory and clinical medicine · 2018Review
- HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Alveolar nonselective channels are ASIC1a/α-ENaC channels and contribute to AFC.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Inflammatory Responses Regulating Alveolar Ion Transport during Pulmonary Infections.Frontiers in immunology · 2017Review
- The O-glycosylated ectodomain of FXYD5 impairs adhesion by disrupting cell-cell trans-dimerization of Na,K-ATPase β1 subunits.Journal of cell science · 2016Article
- Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.The Journal of clinical investigation · 2016Article
- β2-agonists and acute respiratory distress syndrome.American journal of respiratory and critical care medicine · 2014Article
- Nuclear Na+/K+-ATPase plays an active role in nucleoplasmic Ca2+ homeostasis.Journal of cell science · 2012Article
- Evolutionary conserved role of c-Jun-N-terminal kinase in CO2-induced epithelial dysfunction.PloS one · 2012Article
- Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation.Molecular and cellular biology · 2011Article
- Dopamine and renal function and blood pressure regulation.Comprehensive Physiology · 2011Review
- Salt-inducible kinase 1 is present in lung alveolar epithelial cells and regulates active sodium transport.Biochemical and biophysical research communications · 2011Article
- Nasal potential difference to detect Na+ channel dysfunction in acute lung injury.American journal of physiology. Lung cellular and molecular physiology · 2011Review
- The beta1 subunit of the Na,K-ATPase pump interacts with megalencephalic leucoencephalopathy with subcortical cysts protein 1 (MLC1) in brain astrocytes: new insights into MLC pathogenesis.Human molecular genetics · 2011Article
- Dopamine and G protein-coupled receptor kinase 4 in the kidney: role in blood pressure regulation.Biochimica et biophysica acta · 2010Review
- AS160 associates with the Na+,K+-ATPase and mediates the adenosine monophosphate-stimulated protein kinase-dependent regulation of sodium pump surface expression.Molecular biology of the cell · 2010Article
- Extracellular signal-regulated kinase (ERK) participates in the hypercapnia-induced Na,K-ATPase downregulation.FEBS letters · 2010Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 4 countries.
Funding
Abstract
Dopamine (DA) increases Na(+),K(+)-ATPase activity in lung alveolar epithelial cells. This effect is associated with an increase in Na(+),K(+)-ATPase molecules within the plasma membrane (). Analysis of Na(+),K(+)-ATPase motion was performed in real-time in alveolar cells stably expressing Na(+),K(+)-ATPase molecules carrying a fluorescent tag (green fluorescent protein) in the alpha-subunit. The data demonstrate a distinct (random walk) pattern of basal movement of Na(+),K(+)-ATPase-containing vesicles in nontreated cells. DA increased the directional movement (by 3.5 fold) of the vesicles and an increase in their velocity (by 25%) that consequently promoted the incorporation of vesicles into the plasma membrane. The movement of Na(+),K(+)-ATPase-containing vesicles and incorporation into the plasma membrane were microtubule dependent, and disruption of this network perturbed vesicle motion toward the plasma membrane and prevented the increase in the Na(+),K(+)-ATPase activity induced by DA. Thus, recruitment of new Na(+),K(+)-ATPase molecules into the plasma membrane appears to be a major mechanism by which dopamine increases total cell Na(+),K(+)-ATPase activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.