ArticleMolecular biology of the cell2003
Global transcription analysis of Krebs tricarboxylic acid cycle mutants reveals an alternating pattern of gene expression and effects on hypoxic and oxidative genes.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
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- The Impact of Metabolic Scion-Rootstock Interactions in Different Grapevine Tissues and Phloem Exudates.Metabolites · 2021Article
- The interplay between oxidative stress and bioenergetic failure in neuropsychiatric illnesses: can we explain it and can we treat it?Molecular biology reports · 2020Review
- Predicting the vulnerability of birds to trophic threat posed by phenological mismatch based on nutritional and physiological status of nestlings.Conservation physiology · 2019Article
- Pathogenesis and Treatment Options of Cancer Related Anemia: Perspective for a Targeted Mechanism-Based Approach.Frontiers in physiology · 2018Review
- Tricarboxylates Induce Defense Priming Against Bacteria inFrontiers in plant science · 2018Article
- Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.Human molecular genetics · 2016Article
- Mitochondrial retrograde signaling regulates neuronal function.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.Cell cycle (Georgetown, Tex.) · 2015Article
- Genome-wide analysis of Saccharomyces cerevisiae identifies cellular processes affecting intracellular aggregation of Alzheimer's amyloid-β42: importance of lipid homeostasis.Molecular biology of the cell · 2014Article
- Identification of a gene set to evaluate the potential effects of loud sounds from seismic surveys on the ears of fishes: a study with Salmo salar.Journal of fish biology · 2014Article
- Defects in mitochondrial fatty acid synthesis result in failure of multiple aspects of mitochondrial biogenesis in Saccharomyces cerevisiae.Molecular microbiology · 2013Article
- Transcriptomic analysis of the role of carboxylic acids in metabolite signaling in Arabidopsis leaves.Plant physiology · 2013Article
- Article
- Mitochondrial DNA instability in cells lacking aconitase correlates with iron citrate toxicity.Oxidative medicine and cellular longevity · 2013Article
- Alternative splicing regulates targeting of malate dehydrogenase in Yarrowia lipolytica.DNA research : an international journal for rapid publication of reports on genes and genomes · 2012Article
- Ligand binding and structural changes associated with allostery in yeast NAD(+)-specific isocitrate dehydrogenase.Archives of biochemistry and biophysics · 2012Review
- Analysis of cancer metabolism with high-throughput technologies.BMC bioinformatics · 2011Article
- Effects of excess succinate and retrograde control of metabolite accumulation in yeast tricarboxylic cycle mutants.The Journal of biological chemistry · 2011Article
- Whole genome sequencing of Saccharomyces cerevisiae: from genotype to phenotype for improved metabolic engineering applications.BMC genomics · 2010Article
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5 authors.
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Abstract
To understand the many roles of the Krebs tricarboxylic acid (TCA) cycle in cell function, we used DNA microarrays to examine gene expression in response to TCA cycle dysfunction. mRNA was analyzed from yeast strains harboring defects in each of 15 genes that encode subunits of the eight TCA cycle enzymes. The expression of >400 genes changed at least threefold in response to TCA cycle dysfunction. Many genes displayed a common response to TCA cycle dysfunction indicative of a shift away from oxidative metabolism. Another set of genes displayed a pairwise, alternating pattern of expression in response to contiguous TCA cycle enzyme defects: expression was elevated in aconitase and isocitrate dehydrogenase mutants, diminished in alpha-ketoglutarate dehydrogenase and succinyl-CoA ligase mutants, elevated again in succinate dehydrogenase and fumarase mutants, and diminished again in malate dehydrogenase and citrate synthase mutants. This pattern correlated with previously defined TCA cycle growth-enhancing mutations and suggested a novel metabolic signaling pathway monitoring TCA cycle function. Expression of hypoxic/anaerobic genes was elevated in alpha-ketoglutarate dehydrogenase mutants, whereas expression of oxidative genes was diminished, consistent with a heme signaling defect caused by inadequate levels of the heme precursor, succinyl-CoA. These studies have revealed extensive responses to changes in TCA cycle function and have uncovered new and unexpected metabolic networks that are wired into the TCA cycle.
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