ArticleMolecular biology of the cell2003
Peroxisome biogenesis occurs in an unsynchronized manner in close association with the endoplasmic reticulum in temperature-sensitive Yarrowia lipolytica Pex3p mutants.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Peroxisome biogenesis and inter-organelle communication: an indispensable role for Pex11 and Pex30 family proteins in yeast.Current genetics · 2022Review
- A Review of Diatom Lipid Droplets.Biology · 2020Review
- PEX16 contributions to peroxisome import and metabolism revealed by viable Arabidopsis pex16 mutants.Journal of integrative plant biology · 2019Article
- No peroxisome is an island - Peroxisome contact sites.Biochimica et biophysica acta · 2016Review
- Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes.Oncotarget · 2016Article
- Reevaluation of the role of Pex1 and dynamin-related proteins in peroxisome membrane biogenesis.The Journal of cell biology · 2015Article
- Macromitophagy, neutral lipids synthesis, and peroxisomal fatty acid oxidation protect yeast from "liponecrosis", a previously unknown form of programmed cell death.Cell cycle (Georgetown, Tex.) · 2014Article
- The putative Saccharomyces cerevisiae hydrolase Ldh1p is localized to lipid droplets.Eukaryotic cell · 2011Article
- Pex3 peroxisome biogenesis proteins function in peroxisome inheritance as class V myosin receptors.The Journal of cell biology · 2009Article
- The gregarious lipid droplet.The Journal of biological chemistry · 2008Review
- Peroxisome biogenesis: the peroxisomal endomembrane system and the role of the ER.The Journal of cell biology · 2006Review
- An intimate collaboration between peroxisomes and lipid bodies.The Journal of cell biology · 2006Article
- Quantitative mass spectrometry reveals a role for the GTPase Rho1p in actin organization on the peroxisome membrane.The Journal of cell biology · 2004Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pex3p is a peroxisomal integral membrane protein required early in peroxisome biogenesis, and Pex3p-deficient cells lack identifiable peroxisomes. Two temperature-sensitive pex3 mutant strains of the yeast Yarrowia lipolytica were made to investigate the role of Pex3p in the early stages of peroxisome biogenesis. In glucose medium at 16 degrees C, these mutants underwent de novo peroxisome biogenesis and exhibited early matrix protein sequestration into peroxisome-like structures found at the endoplasmic reticulum-rich periphery of cells or sometimes associated with nuclei. The de novo peroxisome biogenesis seemed unsynchronized, with peroxisomes occurring at different stages of development both within cells and between cells. Cells with peripheral nascent peroxisomes and cells with structures morphologically distinct from peroxisomes, such as semi/circular tubular structures that immunostained with antibodies to peroxisomal matrix proteins and to the endoplasmic reticulum-resident protein Kar2p, and that surrounded lipid droplets, were observed during up-regulation of peroxisome biogenesis in cells incubated in oleic acid medium at 16 degrees C. These structures were not detected in wild-type or Pex3p-deficient cells. Their role in peroxisome biogenesis remains unclear. Targeting of peroxisomal matrix proteins to these structures suggests that Pex3p directly or indirectly sequesters components of the peroxisome biogenesis machinery. Such a role is consistent with Pex3p overexpression producing cells with fewer, larger, and clustered peroxisomes.
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