ArticleMolecular biology of the cell2003
Loss of protooncogene c-Myc function impedes G1 phase progression both before and after the restriction point.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Targeting protein synthesis pathways in MYC-amplified medulloblastoma.Discover oncology · 2025Review
- Measuring S-Phase Duration from Asynchronous Cells Using Dual EdU-BrdU Pulse-Chase Labeling Flow Cytometry.Genes · 2022Article
- Thyroid hormone receptor alpha sumoylation modulates white adipose tissue stores.Scientific reports · 2021Article
- MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies.Journal of hematology & oncology · 2021Review
- The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA.PLoS biology · 2021Article
- c-Myc regulates the CDK1/cyclin B1 dependent‑G2/M cell cycle progression by histone H4 acetylation in Raji cells.International journal of molecular medicine · 2018Article
- c-Myc is a novel target of cell cycle arrest by honokiol in prostate cancer cells.Cell cycle (Georgetown, Tex.) · 2016Article
- MYC and the control of DNA replication.Cold Spring Harbor perspectives in medicine · 2014Review
- Article
- Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters.Cell cycle (Georgetown, Tex.) · 2011Article
- Proteomic profiling of Myc-associated proteins.Cell cycle (Georgetown, Tex.) · 2010Article
- The cell cycle time of CD8+ T cells responding in vivo is controlled by the type of antigenic stimulus.PloS one · 2010Article
- Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover.Nature cell biology · 2010Article
- You Don't Muck with MYC.Genes & cancer · 2010Article
- The role of Myc-induced protein synthesis in cancer.Cancer research · 2009Review
- cMyc increases cell number through uncoupling of cell division from cell size in CHO cells.BMC biotechnology · 2009Article
- c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry.Oncogene · 2009Article
- RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells.BMC cancer · 2009Article
- A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression.Molecular and cellular biology · 2008Article
- The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry.Cell cycle (Georgetown, Tex.) · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
c-myc is an important protooncogene whose misregulation is believed to causally affect the development of numerous human cancers. c-myc null rat fibroblasts are viable but display a severe (two- to threefold) retardation of proliferation. The rates of RNA and protein synthesis are reduced by approximately the same factor, whereas cell size remains unaffected. We have performed a detailed kinetic cell cycle analysis of c-myc(-/-) cells by using several labeling and synchronization methods. The majority of cells (>90%) in asynchronous, exponential phase c-myc(-/-) cultures cycle continuously with uniformly elongated cell cycles. Cell cycle elongation is due to a major lengthening of G(1) phase (four- to fivefold) and a more limited lengthening of G(2) phase (twofold), whereas S phase duration is largely unaffected. Progression from mitosis to the G1 restriction point and the subsequent progression from the restriction point into S phase are both drastically delayed. These results are best explained by a model in which c-Myc directly affects cell growth (accumulation of mass) and cell proliferation (the cell cycle machinery) by independent pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.