ReviewGut2003
Non-steroidal anti-inflammatory drugs: overall risks and management. Complementary roles for COX-2 inhibitors and proton pump inhibitors.
Review in Gut, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 178 citations in OpenAlex.
- Impact of safety-related regulatory action on clinical practice: a systematic review.Drug safety · 2012Pooled it
- Identification of NSAID users at risk for gastrointestinal complications: a systematic review of current guidelines and consensus agreements.Drug safety · 2010Pooled it
- Which drugs cause preventable admissions to hospital? A systematic review.British journal of clinical pharmacology · 2007Pooled it
- A randomised, placebo controlled, comparative trial of the gastrointestinal safety and efficacy of AZD3582 versus naproxen in osteoarthritis.Annals of the rheumatic diseases · 2005Trial
- Genomic exploration andFrontiers in bioinformatics · 2026Article
- Mitigation of hepatic and gastric impairments induced by flunixin meglumine through co-administration with alpha lipoic acid in male rats.BMC veterinary research · 2025Article
- The Origins and Proliferation of Unfounded Comparisons Regarding the Safety of Mifepristone.Biotech (Basel (Switzerland)) · 2025Article
- Composition of Whole Grain Dietary Fiber and Phenolics and Their Impact on Markers of Inflammation.Nutrients · 2024Review
- Potentially active aspirin derivative to release nitric oxide:Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- The Safety of Celecoxib as an Acute Treatment for Migraine: A Narrative Review.Pain and therapy · 2023Review
- Immunomodulatory and Antioxidant Effects of Spray-Dried Encapsulated Kale Sprouts afterFoods (Basel, Switzerland) · 2023Article
- Tryptophol Acetate and Tyrosol Acetate, Small-Molecule Metabolites Identified in a Probiotic Mixture, Inhibit Hyperinflammation.Journal of innate immunity · 2023Article
- Combining mussel with fucoidan as a supplement for joint pain and prediabetes: Study protocol for a randomized, double-blinded, placebo-controlled trial.Frontiers in nutrition · 2022Article
- Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects.Molecules (Basel, Switzerland) · 2021Review
- Sex differences in the consumption of over-the-counter analgesics among amateur volleyball players.BMC sports science, medicine & rehabilitation · 2021Article
- Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity.Frontiers in pharmacology · 2021Review
- Heracleum moellendorffii roots inhibit the production of pro-inflammatory mediators through the inhibition of NF-κB and MAPK signaling, and activation of ROS/Nrf2/HO-1 signaling in LPS-stimulated RAW264.7 cells.BMC complementary and alternative medicine · 2019Article
- Anti-inflammatory activity ofSaudi journal of biological sciences · 2019Article
- Nonsteroidal anti-inflammatory drugs for assisted reproductive technology.The Cochrane database of systematic reviews · 2019Review
- Physicochemical, pharmacokinetics, and histological evaluation of new naproxen-quercetin co-lyophilizate to diminish drug-induced gastric irritations in rats.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are well recognised as causing peptic ulceration and ulcer complications. However, several critical issues, including the amount of both gastrointestinal and non-gastrointestinal disease affected by NSAIDs, their interaction with ancillary risk factors, and how to optimise management in subgroups, remain poorly understood. In this article, strategies for subgroups that take account of non-specific gastrointestinal risks, minimisation of residual risk, and the importance of non-gastrointestinal toxicity are suggested, and areas for research identified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.