ArticleGut2003
Hepatic osteodystrophy in rats results mainly from portasystemic shunting.
Article in Gut, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Abernethy syndrome in Slovenian children: Five case reports and review of literature.World journal of gastroenterology · 2020Review
- Osteoporosis and fractures in liver disease: relevance, pathogenesis and therapeutic implications.World journal of gastroenterology · 2014Review
- Clinical manifestations of portal hypertension.International journal of hepatology · 2012Article
- Castration inhibits biliary proliferation induced by bile duct obstruction: novel role for the autocrine trophic effect of testosterone.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Current understanding of osteoporosis associated with liver disease.Nature reviews. Gastroenterology & hepatology · 2009Review
- Comparative effects of scaffold pore size, pore volume, and total void volume on cranial bone healing patterns using microsphere-based scaffolds.Journal of biomedical materials research. Part A · 2009Article
- Ribavirin enhances osteoclast formation through osteoblasts via up-regulation of TRANCE/RANKL.Molecular and cellular biochemistry · 2007Article
- Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting.World journal of gastroenterology · 2006Article
- Bone disorders in experimentally induced liver disease in growing rats.World journal of gastroenterology · 2005Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsIn chronic liver disease, bone disease frequently develops. The contributions of the different features of liver disease such as parenchymal inflammation, portal hypertension, and portasystemic shunting on bone metabolism have not been systematically studied. The aim of this study was to identify the features of liver disease contributing to bone disease using rat models.
methodsParenchymal liver disease was induced by carbon tetrachloride administration, portal hypertension by partial portal vein ligation, and portasystemic shunting by end to side anastomosis of the portal vein to the inferior vena cava. Normal and sham operated surgical animals served as controls. Serum calcium, 25-hydroxy vitamin D (25-OH vit D), and osteocalcin levels, and urinary deoxypyridinoline excretion were analysed. Testosterone and oestradiol levels were determined in male and female rats, respectively. Interleukin 1, interleukin 6, and tumour necrosis factor alpha (TNF-alpha) were determined in serum. Bone density was measured in all groups and in addition, in the surgical groups, histomorphometry was performed on undecalcified specimens of the proximal tibia. The calcium content of the femurs, removed at termination and ashed, was determined.
resultsEarly parenchymal disease and portal hypertension did not affect bone metabolism or body mass. Portasystemic shunting increased bone resorption, decreased bone formation, bone density, and trabecular bone volume which were commensurate with a reduction in body mass. TNF-alpha levels were elevated and testosterone levels were low in male portasystemic shunted rats.
conclusionsPortasystemic shunting in the rat adversely affects bone metabolism as part of a generalised catabolic state where high TNF-alpha and low testosterone and 25-OH vit D levels may play a role.
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