ArticleGut2003
Genetic polymorphisms in biotransformation enzymes in Crohn's disease: association with microsomal epoxide hydrolase.
Article in Gut, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Association of Glutathione S-Transferase M1 null genotype with inflammatory bowel diseases: A systematic review and meta-analysis.Medicine · 2019Pooled it
- GST Theta null genotype is associated with an increased risk for ulcerative colitis: a case-control study and meta-analysis of GST Mu and GST Theta polymorphisms in inflammatory bowel disease.Journal of human genetics · 2014Pooled it
- Association between the GLUT1 gene polymorphism and the risk of diabetic nephropathy: a meta-analysis.Journal of human genetics · 2005Pooled it
- The Association between EPHX1 Gene Polymorphisms and Lung Cancer among Jordanian People.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Association Study of Glutathione S-transferases Gene Polymorphisms (GSTM1 and GSTT1) with Ulcerative Colitis and Crohn's Disease in the South of Iran.Advanced biomedical research · 2017Article
- LPS-Stimulated Whole Blood Cytokine Production Is Not Related to Disease Behavior in Patients with Quiescent Crohn's Disease.PloS one · 2015Article
- Association of microsomal epoxide hydrolase exon 3 Tyr113His and exon 4 His139Arg polymorphisms with gastric cancer in India.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2013Article
- The role of N-acetyltransferase 2 polymorphism in the etiopathogenesis of inflammatory bowel disease.Digestive diseases and sciences · 2011Article
- UGT1A7 polymorphisms in chronic pancreatitis: an example of genotyping pitfalls.The pharmacogenomics journal · 2008Article
- Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian, China.BMC cancer · 2006Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMucosal biotransformation enzymes can modify toxic compounds in the gut. As chemical or oxidative stress may be involved in the aetiology of Crohn's disease, genes encoding for enzymes involved in the prevention of such stress may be candidates for genetic susceptibility to Crohn's disease.
aimTo assess the association of Crohn's disease with genetic polymorphisms in cytochrome P450 1A1, glutathione S-transferases mu-1, pi-1, and theta-1, and epoxide hydrolase.
methodschi(2) square analysis was used to compare frequencies of polymorphisms between 151 patients with Crohn's disease and 149 healthy controls.
resultsIn patients, a genetic polymorphism in exon 3 of the microsomal epoxide hydrolase gene was distributed significantly different compared with controls (chi(2)=23.7; p<0.0001). All other polymorphisms tested were equally distributed between patients and controls.
conclusionsMicrosomal epoxide hydrolase may play a role in the pathophysiology of Crohn's disease. Furthermore, the epoxide hydrolase gene is located on chromosome 1q, close to a region previously linked to Crohn's disease.
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