ArticleGut2003
COX-2 dependent inflammation increases spinal Fos expression during rodent postoperative ileus.
Article in Gut, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 88 citations in OpenAlex.
- Differential responses to prostaglandins in the circular and longitudinal muscle layers of the murine ileum.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- An experimentally validated approach to automated biological evidence generation in drug discovery using knowledge graphs.Nature communications · 2024Article
- The role of beta-adrenoreceptors in postoperative ileus in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Inflammation and Impaired Gut Physiology in Post-operative Ileus: Mechanisms and the Treatment Options.Journal of neurogastroenterology and motility · 2022Review
- Improved motility in the gastrointestinal tract of a postoperative ileus rat model with ilaprazole.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2021Article
- Risk factors for upper and lower type prolonged postoperative ileus following surgery for Crohn's disease.International journal of colorectal disease · 2021Article
- Postoperative Ileus: Comparative Pathophysiology and Future Therapies.Frontiers in veterinary science · 2021Review
- Muscularis macrophages: Key players in intestinal homeostasis and disease.Cellular immunology · 2018Review
- Anti-inflammatory Effects of Enhanced Recovery Programs on Early-Stage Colorectal Cancer Surgery.World journal of surgery · 2018Article
- Electroacupuncture treatment partly promotes the recovery time of postoperative ileus by activating the vagus nerve but not regulating local inflammation.Scientific reports · 2017Article
- Behavioral and physiological characterization of PKC-dependent phosphorylation in the Grin2a∆PKC mouse.Brain research · 2016Article
- The Pharmacological Effects of Benachio-F(®) on Rat Gastrointestinal Functions.Biomolecules & therapeutics · 2015Article
- New therapeutic strategies for postoperative ileus.Nature reviews. Gastroenterology & hepatology · 2012Review
- EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Preoperative short-term parenteral administration of polyunsaturated fatty acids ameliorates intestinal inflammation and postoperative ileus in rodents.Langenbeck's archives of surgery · 2012Article
- Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders.World journal of gastrointestinal pathophysiology · 2011Article
- Anti-inflammatory role of glycine in reducing rodent postoperative inflammatory ileus.Neurogastroenterology and motility · 2011Article
- Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming.The journal of pain · 2010Article
- Impact of central and peripheral TRPV1 and ROS levels on proinflammatory mediators and nociceptive behavior.Molecular pain · 2010Article
- Controlling postoperative ileus by vagal activation.World journal of gastroenterology · 2010Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
aimsCyclooxygenase 2 (COX-2) and prostaglandins (PGs) participate in the pathogenesis of inflammatory postoperative ileus. We sought to determine whether the emerging neuronal modulator COX-2 plays a significant role in primary afferent activation during postoperative ileus using spinal Fos expression as a marker.
methodsRats, and COX-2(+/+) and COX-2(-/-) mice underwent simple intestinal manipulation. The effect of intestinal manipulation on Fos immunoreactivity (IR) in the L(5)-S(1) spinal cord, in situ circumference, and postoperative leucocytic infiltrate of the intestinal muscularis was measured. Postoperative PGE(2) production was measured in peritoneal lavage fluid. The dependence of these parameters on COX-2 was studied in pharmacological (DFU, Merck- Frosst, selective COX-2 inhibitor) and genetic (COX-2(-/-) mice) models.
resultsPostoperative Fos IR increased 3.7-fold in rats and 2.2-fold in mice. Both muscularis leucocytic infiltrate and the circumference of the muscularis increased significantly in rats and COX-2(+/+) mice postoperatively, indicating dilating ileus. Surgical manipulation markedly increased PGE(2) levels in the peritoneal cavity. DFU pretreatment and the genetic absence of COX-2(-/-) prevented dilating ileus, and leucocytic infiltrate was diminished by 40% with DFU and by 54% in COX-2(-/-) mice. DFU reversed postsurgical intra- abdominal PGE(2) levels to normal. Fos IR after intestinal manipulation was attenuated by approximately 50% in DFU treated rats and in COX-2(-/-) mice.
conclusionsPostoperatively, small bowel manipulation causes a significant and prolonged increase in spinal Fos expression, suggesting prolonged primary afferent activation. COX-2 plays a key role in this response. This activation of primary afferents may subsequently initiate inhibitory motor reflexes to the gut, contributing to postoperative ileus.
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Registered trials
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