ArticleGut2003
Fracture experience of patients with coeliac disease: a population based survey.
Article in Gut, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 132 citations in OpenAlex.
- Effect of zoledronic acid on bone mineral density in patients of celiac disease: a prospective, randomized, pilot study.The Indian journal of medical research · 2013Trial
- Prevalence of Osteoporosis and Sarcopenia in Middle-Aged Subjects with Low Back Pain.The Indian journal of radiology & imaging · 2025Article
- Celiac disease and bone.Archives of endocrinology and metabolism · 2022Review
- Clinical-Pathological Conference Series from the Medical University of Graz : Case No 169: A 32-year-old woman with anemia in pregnancy.Wiener klinische Wochenschrift · 2020Article
- Recent advances in celiac disease and refractory celiac disease.F1000Research · 2019Review
- Cigarette smoking and risk of celiac disease: A systematic review and meta-analysis.United European gastroenterology journal · 2018Review
- Extraintestinal manifestations of coeliac disease.Nature reviews. Gastroenterology & hepatology · 2015Review
- Smoking, use of moist snuff and risk of celiac disease: a prospective study.BMC gastroenterology · 2014Article
- Celiac disease and risk of fracture in adults--a review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Review
- Bone mass and mineral metabolism alterations in adult celiac disease: pathophysiology and clinical approach.Nutrients · 2013Review
- Cost-effectiveness of universal serologic screening to prevent nontraumatic hip and vertebral fractures in patients with celiac disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2013Article
- Risk factors and prevalence of osteoporosis in premenopausal women from poor economic backgrounds in Colombia.International journal of women's health · 2013Article
- Osteoporosis in young adults: pathophysiology, diagnosis, and management.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Review
- Evaluation and management of skeletal health in celiac disease: position statement.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2012Review
- Celiac disease: A missed cause of metabolic bone disease.Indian journal of endocrinology and metabolism · 2012Article
- Bone mineralization in celiac disease.Gastroenterology research and practice · 2012Article
- Risk of fracture in celiac disease: gender, dietary compliance, or both?World journal of gastroenterology · 2011Article
- Screening for celiac disease in a North American population: sequential serology and gastrointestinal symptoms.The American journal of gastroenterology · 2011Article
- Celiac disease: an underappreciated issue in women’s health.Women's health (London, England) · 2010Review
- Osteoporosis and gastrointestinal disease.Gastroenterology & hepatology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile coeliac disease is now recognised as being associated with both osteoporosis and osteomalacia, the size of any increase in the risk of fracture in patients with coeliac disease compared with the general population has not been quantified.
aimTo examine the fracture experience of adults with coeliac disease compared with the general population. SUBJECTS: Patients with coeliac disease diagnosed in adulthood and born before 1950, selected from two large population based disease registers, and age and sex frequency matched controls identified from local general practitioner lists.
methodsA four page lifestyle and general health questionnaire which included specific questions about fracture experience.
resultsAnalysis was performed on 244 patients with coeliac disease and 161 controls, giving response rates of 89% and 72%, respectively. Eighty two (35%) coeliac patients and 53 (33%) controls reported ever having sustained one or more fractures, giving an age and sex adjusted odds ratio of 1.05 (95% confidence interval (CI) 0.68-1.62). The most common fracture site reported was the forearm or wrist, with an adjusted odds ratio of 1.21 (95% CI 0.66-2.25) for patients with coeliac disease having had a forearm or wrist fracture. Low trauma fractures were reported by 37 patients with coeliac disease (15.7%) and by 21 controls (13.8%), with an adjusted odds ratio of 1.16 (95% CI 0.65-2.10). The risk of low trauma fracture was slightly higher in coeliac men than women (odds ratio 1.28 compared with 1.12), but this difference was not statistically significant (p=0.84). After adjustment for age, sex, body mass index, and smoking status, patients with coeliac disease reported 13% more low trauma fractures than controls (odds ratio 1.13, 95% CI 0.60-2.12). There was no difference in low trauma fracture risk before and after diagnosis of coeliac disease.
conclusionNo overall increased fracture risk in patients with coeliac disease was observed. Although severe osteoporosis may develop in a subset of patients, as a whole patients with coeliac disease do not represent a population at particularly high risk of osteoporotic fracture and thus targeting them for osteoporosis screening and treatment is not justified.
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