ReviewBreast cancer research : BCR2003
Is there a role for Notch signalling in human breast cancer?
Review in Breast cancer research : BCR, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Notch signaling activation in pediatric low-grade astrocytoma.Journal of neuropathology and experimental neurology · 2015Article
- Lateral inhibition of Notch signaling in neoplastic cells.Oncotarget · 2015Article
- Article
- Modeling cell-cell interactions in regulating multiple myeloma initiating cell fate.IEEE journal of biomedical and health informatics · 2014Article
- Article
- The anthelmintic drug niclosamide induces apoptosis, impairs metastasis and reduces immunosuppressive cells in breast cancer model.PloS one · 2014Article
- Analysis of Notch and TGF-β Signaling Expression in Different Stages of Disease Progression During Hepatitis B Virus Infection.Clinical and translational gastroenterology · 2012Article
- Aberrant expression of β-catenin and its association with ΔNp63, Notch-1, and clinicopathological factors in oral squamous cell carcinoma.Clinical oral investigations · 2012Article
- Therapeutic efficacy by targeting correction of Notch1-induced aberrants in uveal tumors.PloS one · 2012Article
- Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2011Article
- Cancer stem cell, niche and EGFR decide tumor development and treatment response: A bio-computational simulation study.Journal of theoretical biology · 2011Article
- Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis.Molecular cancer · 2009Article
- Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling.Cancer biology & therapy · 2009Article
- ErbB2 induces Notch1 activity and function in breast cancer cells.Clinical and translational science · 2008Article
- Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2008Review
- Breast cancer, stem cells and prospects for therapy.Breast cancer research : BCR · 2006Review
- Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium.The American journal of pathology · 2004Article
- Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells.Breast cancer research : BCR · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Aberrant Notch signalling has been observed in several human cancers, including acute T-cell lymphoblastic leukaemia and cervical cancer, and is strongly implicated in tumourigenesis. Unregulated Notch signalling in the mouse mammary gland leads to tumour formation. These results raise the possibility that Notch signalling might play a role in human breast cancer. There are currently few reports that address this question directly and this appears to be an area worthy of further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.