ArticleBreast cancer research : BCR2003
Beta-catenin: a transforming actor on many stages.
Article in Breast cancer research : BCR, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- Lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of prostate carcinogenesis.GeroScience · 2024Article
- Recent advances in targeting the "undruggable" proteins: from drug discovery to clinical trials.Signal transduction and targeted therapy · 2023Review
- Targeting Transcription Factors in Cancer: From "Undruggable" to "Druggable".Methods in molecular biology (Clifton, N.J.) · 2023Article
- In vivo imaging of mammary epithelial cell dynamics in response to lineage-biased Wnt/β-catenin activation.Cell reports · 2022Article
- Anti-tumor activity of resveratrol against gastric cancer: a review of recent advances with an emphasis on molecular pathways.Cancer cell international · 2021Review
- Effect of STC2 gene silencing on colorectal cancer cells.Molecular medicine reports · 2019Article
- Interplay Between SOX9, Wnt/β-Catenin and Androgen Receptor Signaling in Castration-Resistant Prostate Cancer.International journal of molecular sciences · 2019Review
- GALNT6 Promotes Tumorigenicity and Metastasis of Breast Cancer Cell via β-catenin/MUC1-C Signaling Pathway.International journal of biological sciences · 2019Article
- Comprehensive integrated analysis of gene expression datasets identifies key anti-cancer targets in different stages of breast cancer.Experimental and therapeutic medicine · 2018Article
- Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway.Oncology letters · 2018Article
- Inhibitory effects of aesculetin on the proliferation of colon cancer cells by the Wnt/β-catenin signaling pathway.Oncology letters · 2018Article
- Revisiting the role of Wnt/β-catenin signaling in prostate cancer.Molecular and cellular endocrinology · 2018Review
- Cross Talk between Wnt/β-Catenin and CIP2A/Plk1 Signaling in Prostate Cancer: Promising Therapeutic Implications.Molecular and cellular biology · 2016Review
- Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.Oncogene · 2015Article
- Monitoring interactions and dynamics of endogenous beta-catenin with intracellular nanobodies in living cells.Molecular & cellular proteomics : MCP · 2015Article
- BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway.Oncology reports · 2015Article
- Wnt inhibition leads to improved chemosensitivity in paediatric acute lymphoblastic leukaemia.British journal of haematology · 2014Article
- MDA-9/Syntenin regulates differentiation and angiogenesis programs in head and neck squamous cell carcinoma.Oncoscience · 2014Article
- Esculetin suppresses proliferation of human colon cancer cells by directly targeting β-catenin.Cancer prevention research (Philadelphia, Pa.) · 2013Article
- Conditional deletion of β-catenin in mammary epithelial cells of Ron receptor, Mst1r, overexpressing mice alters mammary tumorigenesis.Endocrinology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Mutations and deletions that result in the stabilization of beta-catenin are frequently found in a number of tumors, including those of the colon, the liver and the ovary, but are less frequently found in breast cancer. To investigate and understand the molecular nature of cell-specific beta-catenin signaling, experimental mouse genetics has been employed extensively. Gain-of-function and loss-of-function mutations have provided evidence that beta-catenin plays essential roles in development and tumorigenesis. Specifically, the Wnt/beta-catenin signaling pathway controls cell fate decisions throughout development, and a unique role in differentiated epithelia has emerged. Not only beta-catenin, but also the activation of other components of this pathway in differentiated mammary epithelium and prostate epithelium of transgenic mice can induce neoplasias and transdifferentiation to squamous metaplasias. This suggests that the Wnt/beta-catenin pathway is dominant over existing differentiation programs and can impose an epidermal fate or neoplasias onto a variety of cell types. Although there is evidence for a contextual specificity of the Wnt signaling, the experimental systems and designs used in different studies probably influence the cellular responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.