ArticleJournal of muscle research and cell motility2002
The effects of physical activity and estrogen treatment on rat fast and slow skeletal muscles following ovariectomy.
Article in Journal of muscle research and cell motility, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 77 citations in OpenAlex.
- Gender differences for frailty in HIV-infected patients on stable antiretroviral therapy and with an undetectable viral load.PloS one · 2019Trial
- The influence of trait anxiety on performance in the CatWalk test.Frontiers in behavioral neuroscience · 2026Article
- The hypothalamic estrogen receptor α pathway is involved in high-intensity interval training-induced visceral fat loss in premenopausal rats.Lipids in health and disease · 2025Article
- Advantage of ostarine over raloxifene and their combined treatments for muscle of estrogen-deficient rats.Journal of endocrinological investigation · 2024Article
- Estrogen deficiency reduces maximal running capacity and affects serotonin levels differently in the hippocampus and nucleus accumbens in response to acute exercise.Frontiers in neuroscience · 2024Article
- An integrated study of hormone-related sarcopenia for modeling and comparative transcriptome in rats.Frontiers in endocrinology · 2023Article
- Sex hormone-mediated change on muscle activation deactivation dynamics in young eumenorrheic women.Frontiers in physiology · 2023Article
- Clicker Training Mice for Improved Compliance in the Catwalk Test.Animals : an open access journal from MDPI · 2022Article
- Aerobic exercise prevents apoptosis in skeletal muscles of high-fat-fed ovariectomized rats.Physical activity and nutrition · 2022Article
- Role of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass: A Follow-Up Study in Middle-Aged Finnish Women.Journal of clinical medicine · 2020Article
- A Tutorial of the Effects of Sex Hormones on Laryngeal Senescence and Neuromuscular Response to Exercise.Journal of speech, language, and hearing research : JSLHR · 2019Review
- Effects of ovarian hormones and estrogen receptor α on physical activity and skeletal muscle fatigue in female mice.Experimental gerontology · 2019Article
- Muscle-Specific Sensitivity to Voluntary Physical Activity and Detraining.Frontiers in physiology · 2019Article
- Knee extension rate of torque development and peak torque: associations with lower extremity function.Journal of cachexia, sarcopenia and muscle · 2018Article
- Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice.Skeletal muscle · 2016Article
- Effects of intrinsic aerobic capacity and ovariectomy on voluntary wheel running and nucleus accumbens dopamine receptor gene expression.Physiology & behavior · 2016Article
- Estradiol modulates myosin regulatory light chain phosphorylation and contractility in skeletal muscle of female mice.American journal of physiology. Endocrinology and metabolism · 2016Article
- A method to study the impact of chemically-induced ovarian failure on exercise capacity and cardiac adaptation in mice.Journal of visualized experiments : JoVE · 2014Article
- Adiponectin alleviates genioglossal mitochondrial dysfunction in rats exposed to intermittent hypoxia.PloS one · 2014Article
- Voluntary exercise impairs initial delayed spatial alternation performance in estradiol treated ovariectomized middle-aged rats.Hormones and behavior · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decreased estrogen production is associated with changes in the skeletal, cardiovascular and muscular systems. At the level of skeletal muscles, it has been shown that a reduction in force production occurs at menopause but the underlying mechanisms are still unknown. The aim of the study was to investigate the effects of ovariectomy on myosin heavy chain (MyHC) composition. Additionally, we studied the effects of physical activity and the combined effects of physical activity and estrogen treatment on MyHC content in ovariectomised (OX) animals. Twenty-five rats were randomly assigned to five different groups: controls, runners, OX, ovariectomised runners and ovariectomised runners receiving estrogen. Exercise consisted of voluntary running for 5 weeks. Two muscles were analysed: m. extensor digitorum longus, EDL, (fast muscle) and m. soleus (slow muscle). MyHC content was analysed on 8% gel electrophoresis. The level of running activity is reduced in OX animals and estrogen administration is associated with the normalisation of the level of physical activity. Ovariectomy induces a shift from fast to slow MyHC isoforms in both the soleus and EDL. When OX animals are allowed to run, alterations in MyHC isoforms are still observed in the EDL but not in the soleus. When physical activity is combined with estrogen treatment no alterations are observed in both muscles. In conclusion, this study shows that ovariectomy induces alterations in the contractile properties of skeletal muscles and that physical activity in combination with estrogen treatment are associated with the maintenance of slow and fast muscle characteristics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.