ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Reversible disorganization of the locomotor pattern after neonatal spinal cord transection in the rat.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 76 citations in OpenAlex.
- Immediate Consequences of a Spinal Cord Injury During Development: Unique Insights From Ex Vivo Models.Neural plasticity · 2026Review
- KCC2 phosphorylation dynamics relate to oligomerization during development and after spinal cord injury.Frontiers in molecular neuroscience · 2026Article
- Neurotransmitter phenotype switching by spinal excitatory interneurons regulates locomotor recovery after spinal cord injury.Nature neuroscience · 2022Article
- A preliminary investigation of high retinoic acid exposure during fetal development on behavioral competency and litter characteristics in newborn rats.Brain and behavior · 2021Article
- Serotonin in Animal Cognition and Behavior.International journal of molecular sciences · 2020Review
- Retracing your footsteps: developmental insights to spinal network plasticity following injury.Journal of neurophysiology · 2018Review
- Model of Traumatic Spinal Cord Injury for Evaluating Pharmacologic Treatments in Cynomolgus Macaques (Comparative medicine · 2018Article
- Stimulation of 5-HT2A receptors recovers sensory responsiveness in acute spinal neonatal rats.Behavioral neuroscience · 2017Article
- Developmental plasticity of coordinated action patterns in the perinatal rat.Developmental psychobiology · 2015Review
- Article
- Inter- and intralimb adaptations to a sensory perturbation during activation of the serotonin system after a low spinal cord transection in neonatal rats.Frontiers in neural circuits · 2014Article
- Serotonergic modulation of post-synaptic inhibition and locomotor alternating pattern in the spinal cord.Frontiers in neural circuits · 2014Review
- The impact of discrete modes of spinal cord injury on bladder muscle contractility.BMC urology · 2013Article
- Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Enabling techniques for in vitro studies on mammalian spinal locomotor mechanisms.Frontiers in bioscience (Landmark edition) · 2012Review
- Sensory feedback modulates quipazine-induced stepping behavior in the newborn rat.Behavioural brain research · 2012Article
- Adaptations in glutamate and glycine content within the lumbar spinal cord are associated with the generation of novel gait patterns in rats following neonatal spinal cord transection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Locomotor-activated neurons of the cat. II. Noradrenergic innervation and colocalization with NEα 1a or NEα 2b receptors in the thoraco-lumbar spinal cord.Journal of neurophysiology · 2011Article
- Differential plasticity of the GABAergic and glycinergic synaptic transmission to rat lumbar motoneurons after spinal cord injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Locomotor-activated neurons of the cat. I. Serotonergic innervation and co-localization of 5-HT7, 5-HT2A, and 5-HT1A receptors in the thoraco-lumbar spinal cord.Journal of neurophysiology · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The central pattern generators (CPGs) for locomotion, located in the lumbar spinal cord, are functional at birth in the rat. Their maturation occurs during the last few days preceding birth, a period during which the first projections from the brainstem start to reach the lumbar enlargement of the spinal cord. The goal of the present study was to investigate the effect of suppressing inputs from supraspinal structures on the CPGs, shortly after their formation. The spinal cord was transected at the thoracic level at birth [postnatal day 0 (P0)]. We examined during the first postnatal week the capacity of the CPGs to produce rhythmic motor activity in two complementary experimental conditions. Left and right ankle extensor muscles were recorded in vivo during airstepping, and lumbar ventral roots were recorded in vitro during pharmacologically evoked fictive locomotion. Mechanical stimulation of the tail elicited long-lasting sequences of airstepping in the spinal neonates and only a few steps in sham-operated rats. In vitro experiments made simultaneously on spinal and sham animals confirmed the increased excitability of the CPGs after spinalization. A left-right alternating locomotor pattern was observed at P1-P3. Both types of experiments showed that the pattern was disorganized at P6-P7, and that the left-right alternation was lost. Alternation was restored after the activation of serotonergic 5-HT(2) receptors in vivo. These results suggest that descending pathways, in particular serotonergic projections, control the strength of reciprocal inhibition and therefore shape the locomotor pattern in the neonatal rat.
Indexed as
Identifiers
12629197PMC6741960W1787817940What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.