ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Redistribution of syntaxin mRNA in neuronal cell bodies regulates protein expression and transport during synapse formation and long-term synaptic plasticity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Dynamics of Hippocampal Protein Expression During Long-term Spatial Memory Formation.Molecular & cellular proteomics : MCP · 2016Article
- Asymmetric localization of natural antisense RNA of neuropeptide sensorin in Aplysia sensory neurons during aging and activity.Frontiers in genetics · 2014Article
- Targeting RNA-splicing for SMA treatment.Molecules and cells · 2012Review
- Role of protein kinase C in the induction and maintenance of serotonin-dependent enhancement of the glutamate response in isolated siphon motor neurons of Aplysia californica.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Different phases of long-term memory require distinct temporal patterns of PKA activity after single-trial classical conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2008Article
- Protein kinase C regulates local synthesis and secretion of a neuropeptide required for activity-dependent long-term synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation.The Journal of cell biology · 2006Article
- Analysis of knock-out mice to determine the role of HPC-1/syntaxin 1A in expressing synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Two mRNA-binding proteins regulate the distribution of syntaxin mRNA in Aplysia sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Two signaling pathways regulate the expression and secretion of a neuropeptide required for long-term facilitation in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Target-dependent release of a presynaptic neuropeptide regulates the formation and maturation of specific synapses in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- The two regulatory subunits of aplysia cAMP-dependent protein kinase mediate distinct functions in producing synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- RNA translation in axons.Annual review of cell and developmental biology · 2004Review
- Axonal transport of eukaryotic translation elongation factor 1alpha mRNA couples transcription in the nucleus to long-term facilitation at the synapse.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Local translation of mRNAs in neural development.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Syntaxin has an important role in regulating vesicle docking and fusion essential for neurotransmitter release. Here, we demonstrate that the distribution of syntaxin mRNA in cell bodies of sensory neurons (SNs) of Aplysia maintained in cell culture is affected by synapse formation, synapse stabilization, and long-term facilitation (LTF) produced by 5-HT. The distribution of the mRNA in turn regulates expression and axonal transport of the protein. Syntaxin mRNA and protein accumulated at the axon hillock of SNs during the initial phase of synapse formation. Significant numbers of granules containing syntaxin were detected in the SN axon. When synaptic strength was stable, both mRNA and protein were targeted away from the axon hillock, and the number of syntaxin granules in the SN axon was reduced. Dramatic increases in mRNA and protein accumulation at the axon hillock and number of syntaxin granules in the SN axon were produced when cultures with stable connections were treated with 5-HT that evoked LTF. Anisomycin (protein synthesis inhibitor) or KT5720 (protein kinase A inhibitor) blocked LTF, accumulation of syntaxin mRNA and protein at the axon hillock, and the increase in syntaxin granules in SN axons. The results indicate that without significant effects on overall mRNA expression, both target interaction and 5-HT via activation of protein kinase A pathway regulate expression of syntaxin and its packaging for transport into axons by influencing the distribution of its mRNA in the SN cell body.
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Identifiers
12629184PMC6741965W1485333452What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.