ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Sensory neuron subtypes have unique substratum preference and receptor expression before target innervation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- Communicating pain: emerging axonal signaling in peripheral neuropathic pain.Frontiers in neuroanatomy · 2024Review
- Identification of sensory and motor nerve fascicles by immunofluorescence staining after peripheral nerve injury.Journal of translational medicine · 2021Article
- Electric Field Stimulation for the Functional Assessment of Isolated Dorsal Root Ganglion Neuron Excitability.Annals of biomedical engineering · 2021Article
- Bioenergetic Requirements and Spatiotemporal Profile of Nerve Growth Factor Induced PI3K-Akt Signaling Along Sensory Axons.Frontiers in molecular neuroscience · 2021Article
- Decellularization techniques and their applications for the repair and regeneration of the nervous system.Methods (San Diego, Calif.) · 2020Review
- Article
- CSPGs inhibit axon branching by impairing mitochondria-dependent regulation of actin dynamics and axonal translation.Developmental neurobiology · 2017Article
- In vitro models of axon regeneration.Experimental neurology · 2017Review
- Mechanosensing is critical for axon growth in the developing brain.Nature neuroscience · 2016Article
- Isolation and culture of dissociated sensory neurons from chick embryos.Journal of visualized experiments : JoVE · 2014Article
- Integrins and cAMP mediate netrin-induced growth cone collapse.Brain research · 2013Article
- Positional differences of axon growth rates between sensory neurons encoded by Runx3.The EMBO journal · 2012Article
- Regulation of axonal outgrowth and pathfinding by integrin-ECM interactions.Developmental neurobiology · 2011Review
- Nerve growth factor induces axonal filopodia through localized microdomains of phosphoinositide 3-kinase activity that drive the formation of cytoskeletal precursors to filopodia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Selective expression of a sodium pump isozyme by cough receptors and evidence for its essential role in regulating cough.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Shh influences cell number and the distribution of neuronal subtypes in dorsal root ganglia.Developmental biology · 2008Article
- Developmental regulation of sensory axon regeneration in the absence of growth cones.Journal of neurobiology · 2006Article
- Retinoic acid influences anteroposterior positioning of epidermal sensory neurons and their gene expression in a developing chordate (amphioxus).Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Cloning and characterization of chicken α5 integrin: endogenous and experimental expression in early chicken embryos.Matrix biology : journal of the International Society for Matrix BiologyArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The factors controlling the specification and subsequent differentiation of sensory neurons are poorly understood. Data from embryological manipulations suggest that either sensory neuron fates are specified by the targets they encounter or sensory neurons are considerably more "plastic" with respect to specification than are neurons of the CNS. The prevailing view that sensory neurons are specified late in development is not consistent, however, with the directed outgrowth of sensory neurons to their targets and the characteristic spatial distribution of sensory neuron fates within the peripheral ganglia. To address when in development different classes of sensory neurons can first be distinguished, we investigated the interactions of early dorsal root ganglia neurons with the extracellular matrix before neurite outgrowth to targets. We found that subclasses of sensory neurons in early dorsal root ganglia show different patterns of neurite outgrowth and integrin expression that are predictive of their fates. In the absence of neurotrophins, presumptive proprioceptive neurons extend neurites robustly on both laminin and fibronectin, whereas presumptive cutaneous neurons show a strong preference for laminin. Cutaneous afferents that have innervated targets show a similar strong preference for laminin and show higher levels of integrin alpha7beta1 than do proprioceptive neurons. Finally, presumptive proprioceptive neurons express fibronectin receptors, integrin alpha3beta1, alpha4beta1, and alpha5beta1, at higher levels than do presumptive cutaneous neurons. Our results indicate that subtypes of sensory neurons have unique patterns of neurite outgrowth and receptor expression before target innervation.
Indexed as
Identifiers
12629182PMC6741987W1834115420What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.