ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Afterhyperpolarization regulates firing rate in neurons of the suprachiasmatic nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- Article
- Neuropeptide-Dependent Spike Time Precision and Plasticity in Circadian Output Neurons.The European journal of neuroscience · 2025Article
- Effect of a sensing charge mutation on the deactivation of KV7.2 channels.The Journal of general physiology · 2024Article
- Deleting IP6K1 stabilizes neuronal sodium-potassium pumps and suppresses excitability.Molecular brain · 2024Article
- Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP.BMC neuroscience · 2023Article
- Contribution of tetrodotoxin-resistant persistent NaThe journal of headache and pain · 2022Article
- BK channel activation by L-type CaJournal of neurophysiology · 2021Article
- Contributions of CaFrontiers in physiology · 2021Article
- Ion Channels Controlling Circadian Rhythms in Suprachiasmatic Nucleus Excitability.Physiological reviews · 2020Review
- Diurnal properties of voltage-gated CaThe Journal of physiology · 2020Article
- Pathophysiology in the suprachiasmatic nucleus in mouse models of Huntington's disease.Journal of neuroscience research · 2018Article
- Differential regulation of nimodipine-sensitive and -insensitive CaJournal of biomedical science · 2018Article
- Differential contribution of CaThe Journal of general physiology · 2018Article
- Novel description of the large conductance CaPhysiological reports · 2017Article
- Membrane Currents, Gene Expression, and Circadian Clocks.Cold Spring Harbor perspectives in biology · 2017Review
- Transient voltage-activated KJournal of neurophysiology · 2017Article
- BK channel inactivation gates daytime excitability in the circadian clock.Nature communications · 2016Article
- Distinct Firing Properties of Vasoactive Intestinal Peptide-Expressing Neurons in the Suprachiasmatic Nucleus.Journal of biological rhythms · 2016Article
- Review: CaThe open neurology journal · 2016Article
- BK Channels in the Central Nervous System.International review of neurobiology · 2016Review
1 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
Funding
Abstract
Cluster I neurons of the suprachiasmatic nucleus (SCN), which are thought to be pacemakers supporting circadian activity, fire spontaneous action potentials that are followed by a monophasic afterhyperpolarization (AHP). Using a brain slice preparation, we have found that the AHP has a shorter duration in cells firing at higher frequency, consistent with circadian modulation of the AHP. The AHP is supported by at least three subtypes of K(Ca) channels, including apamin-sensitive channels, iberiotoxin-sensitive channels, and channels that are insensitive to both of these antagonists. The latter K(Ca) channel subtype is involved in rate-dependent regulation of the AHP. Voltage-clamped, whole-cell Ca(2+) channel currents recorded from SCN neurons were dissected pharmacologically, revealing all of the major high-voltage activated subtypes: L-, N-, P/Q-, and R-type Ca(2+) channel currents. Application of Ca(2+) channel antagonists to spontaneously firing neurons indicated that predominantly L- and R-type currents trigger the AHP. Our findings suggest that apamin- and iberiotoxin-insensitive K(Ca) channels are subject to diurnal modulation by the circadian clock and that this modulation either directly or indirectly leads to the expression of a circadian rhythm in spiking frequency.
Indexed as
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12629163PMC6741980What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.