ArticleThe Journal of experimental medicine2003
Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferation.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 144 citations in OpenAlex.
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- CD4+ Memory T Cells at Home in the Tissue: Mechanisms for Health and Disease.Frontiers in immunology · 2018Review
- Co-delivery of autoantigen and dexamethasone in incomplete Freund's adjuvant ameliorates experimental autoimmune encephalomyelitis.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Vaccines targeting helper T cells for cancer immunotherapy.Current opinion in immunology · 2017Review
- The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia.Mediators of inflammation · 2017Article
- T Cell Vaccinology: Beyond the Reflection of Infectious Responses.Trends in immunology · 2016Review
- Regulatory T cell memory.Nature reviews. Immunology · 2016Review
- Adjuvants for peptide-based cancer vaccines.Journal for immunotherapy of cancer · 2016Review
- Controlling the fire--tissue-specific mechanisms of effector regulatory T-cell homing.Immunology and cell biology · 2015Review
- Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection.PLoS pathogens · 2014Article
- Cancer vaccines: Trafficking of tumor-specific T cells to tumor after therapeutic vaccination.The international journal of biochemistry & cell biology · 2014Review
- Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection.Nature communications · 2014Article
- Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues.Immunity · 2014Article
- Organ-specific and memory treg cells: specificity, development, function, and maintenance.Frontiers in immunology · 2014Review
- CD4 T-cell memory generation and maintenance.Critical reviews in immunology · 2014Review
- Physiological and molecular determinants of embryo implantation.Molecular aspects of medicine · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The migration of antigen-specific T cells to nonlymphoid tissues is thought to be important for the elimination of foreign antigens from the body. However, recent results showing the migration of activated T cells into many nonlymphoid tissues raised the possibility that antigen-specific T cells do not migrate preferentially to nonlymphoid tissues containing antigen. We addressed this question by tracking antigen-specific CD4 T cells in the whole body after a localized subcutaneous antigen injection. Antigen-specific CD4 T cells proliferated in the skin-draining lymph nodes and the cells that underwent the most cell divisions acquired the ability to bind to CD62P. As time passed, CD62P-binding antigen-specific CD4 T cells with interferon gamma production potential accumulated preferentially at the site of antigen injection but only in recipients that expressed CD62E. Surprisingly, these T cells did not proliferate in the injection site despite showing evidence of more cell divisions than the T cells in the draining lymph nodes. The results suggest that the most divided effector CD4 T cells from the lymph nodes enter the site of antigen deposition via recognition of CD62E on blood vessels and are retained there in a nonproliferative state via recognition of peptide-major histocompatibility complex II molecules.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.