ArticleCurrent treatment options in gastroenterology2003
Intrahepatic Cholestasis of Pregnancy.
Article in Current treatment options in gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 66 citations in OpenAlex.
- Article
- Management of Intrahepatic Cholestasis of Pregnancy: Recommendations of the Working Group on Obstetrics and Prenatal Medicine - Section on Maternal Disorders.Geburtshilfe und Frauenheilkunde · 2021Article
- [Intrahepatic cholestasis of pregnancy].Der Gynakologe · 2021Article
- Relationship between early onset severe intrahepatic cholestasis of pregnancy and higher risk of meconium-stained fluid.PloS one · 2017Article
- Immunology of hepatic diseases during pregnancy.Seminars in immunopathology · 2016Review
- Effect of ursodeoxycholic acid treatment on the altered progesterone and bile acid homeostasis in the mother-placenta-foetus trio during cholestasis of pregnancy.British journal of clinical pharmacology · 2015Article
- Role of macrophages in bile acid-induced inflammatory response of fetal lung during maternal cholestasis.Journal of molecular medicine (Berlin, Germany) · 2014Article
- A comprehensive analysis of common genetic variation around six candidate loci for intrahepatic cholestasis of pregnancy.The American journal of gastroenterology · 2014Article
- Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice.The Journal of clinical investigation · 2009Article
- Excretion of biliary compounds during intrauterine life.World journal of gastroenterology · 2009Review
- The Multiple Facets of ABCB4 (MDR3) Deficiency.Current treatment options in gastroenterology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intrahepatic cholestasis of pregnancy (or obstetric cholestasis) is a liver disorder that occurs in late pregnancy. Despite the potential adverse maternal and fetal/neonatal outcomes, cholestasis of pregnancy is often neglected and treated expectantly. More research is needed to improve the molecular and genetic understanding of the disease and to define a safe and effective medical treatment that improves clinical outcome. Ursodeoxycholic acid is considered to be a safe treatment option in the third trimester, but further randomized controlled trials are needed before ursodeoxycholic acid treatment can be generally recommended. Ursodeoxycholic acid is preferentially administered to patients with severe cholestasis (onset before week 33 or serum bile acid levels > 70 mmol/L) or to patients with a history of sudden fetal death, while maintaining close obstetric and regular biochemical surveillance (transaminases, bilirubin, and bile acid levels). Ursodeoxycholic acid can decrease pruritus and ameliorate liver tests, but effects on obstetric complications are ambiguous. S-Adenosylmethionine, dexamethasone, and cholestyramine can provide some relief of itching. Because none of these drugs have been shown to be harmful to mother or fetus, the individual woman and her clinician may decide whether to try one of the treatments described.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.