ArticleProceedings of the National Academy of Sciences of the United States of America2003
Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
65 citing papers in PubMed, 212 citations in OpenAlex.
- WNT Signaling in Stem Cells: A Look into the Non-Canonical Pathway.Stem cell reviews and reports · 2024Review
- Yolk sac cell atlas reveals multiorgan functions during human early development.Science (New York, N.Y.) · 2023Article
- HIF2 Regulates Intestinal Wnt5a Expression.Frontiers in oncology · 2021Article
- Review
- Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling.Experimental & molecular medicine · 2020Article
- Src and Fyn define a new signaling cascade activated by canonical and non-canonical Wnt ligands and required for gene transcription and cell invasion.Cellular and molecular life sciences : CMLS · 2020Article
- Targeting cancer stem cells in drug discovery: Current state and future perspectives.World journal of stem cells · 2019Review
- Defective WNT signaling associates with bone marrow fibrosis-a cross-sectional cohort study in a family with WNT1 osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Article
- Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells.The Journal of experimental medicine · 2017Article
- Wnt Signaling: Role in Regulation of Haematopoiesis.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2016Review
- Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells.Blood · 2015Article
- The Role of Genetically Modified Mesenchymal Stem Cells in Urinary Bladder Regeneration.PloS one · 2015Article
- Wnt inhibition leads to improved chemosensitivity in paediatric acute lymphoblastic leukaemia.British journal of haematology · 2014Article
- Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor.Stem cells (Dayton, Ohio) · 2014Article
- The role of novel and known extracellular matrix and adhesion molecules in the homeostatic and regenerative bone marrow microenvironment.Cell adhesion & migration · 2014Review
- Ex vivo expansion of functional human UCB-HSCs/HPCs by coculture with AFT024-hkirre cells.BioMed research international · 2014Article
- Wnt1 Accelerates an Ex Vivo Expansion of Human Cord Blood CD34(+)CD38(-) Cells.Stem cells international · 2013Article
- Increasing hematopoietic stem cell yield to develop mice with human immune systems.BioMed research international · 2013Review
- Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human hematopoietic stem cells are defined by their ability to repopulate multiple hematopoietic lineages in the bone marrow of transplanted recipients and therefore are functionally distinct from hematopoietic progenitors detected in vitro. Although factors capable of regulating progenitors are well established, in vivo regulators of hematopoietic repopulating function are unknown. By using a member of the vertebrate Wnt family, Wnt-5A, the proliferation and differentiation of progenitors cocultured on stromal cells transduced with Wnt-5A or treated with Wnt-5A conditioned medium (CM) was unaffected. However, i.p. injection of Wnt-5A CM into mice engrafted with human repopulating cells increased multilineage reconstitution by >3-fold compared with controls. Furthermore, in vivo treatment of human repopulating cells with Wnt-5A CM produced a greater proportion of phenotypically primitive hematopoietic progeny that could be isolated and shown to possess enhanced progenitor function independent of continued Wnt-5A treatment. Our study demonstrates that Wnt-5A augments primitive hematopoietic development in vivo and represents an in vivo regulator of hematopoietic stem cell function in the human. Based on these findings, we suggest a potential role for activation of Wnt signaling in managing patients exhibiting poor hematopoietic recovery shortly after stem cell transplantation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.