ArticleProceedings of the National Academy of Sciences of the United States of America2003
Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 99 citations in OpenAlex.
- Diverse functions and pathogenetic role of Crumbs in retinopathy.Cell communication and signaling : CCS · 2024Review
- SPTBN1 Mediates the Cytoplasmic Constraint of PTTG1, Impairing Its Oncogenic Activity in Human Seminoma.International journal of molecular sciences · 2023Article
- Article
- Pituitary Tumor-Transforming Gene 1/Delta like Non-Canonical Notch Ligand 1 Signaling in Chronic Liver Diseases.International journal of molecular sciences · 2022Review
- Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas.Journal of pathology and translational medicine · 2022Article
- GH and Senescence: A New Understanding of Adult GH Action.Journal of the Endocrine Society · 2022Review
- ZBED6 counteracts high-fat diet-induced glucose intolerance by maintaining beta cell area and reducing excess mitochondrial activation.Diabetologia · 2021Article
- Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1Metabolism: clinical and experimental · 2021Article
- Nuclear Localization of PTTG1 Promotes Migration and Invasion of Seminoma Tumor through Activation of MMP-2.Cancers · 2021Article
- A moderate physiological dose of benzyl butyl phthalate exacerbates the high fat diet-induced diabesity in male mice.Toxicology research · 2020Article
- Article
- Spatial learning and long-term memory impairments in RasGrf1 KO, Pttg1 KO, and double KO mice.Brain and behavior · 2018Article
- TCF1 links GIPR signaling to the control of beta cell function and survival.Nature medicine · 2016Article
- Transcriptional profiling reveals functional links between RasGrf1 and Pttg1 in pancreatic beta cells.BMC genomics · 2014Article
- Cellular senescence: from physiology to pathology.Nature reviews. Molecular cell biology · 2014Review
- Pituitary tumor-transforming gene 1 regulates the patterning of retinal mosaics.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- In silico discovery of mitosis regulation networks associated with early distant metastases in estrogen receptor positive breast cancers.Cancer informatics · 2013Article
- Down-regulation of the oncogene PTTG1 via the KLF6 tumor suppressor during induction of myeloid differentiation.PloS one · 2013Article
- Article
- Pituitary tumor transforming gene induces epithelial to mesenchymal transition by regulation of Twist, Snail, Slug, and E-cadherin.Cancer letters · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian securin, pituitary tumor transforming gene (PTTG), regulates sister chromatid separation during mitosis. Mice or cell lines deficient in PTTG expression, however, are surprisingly viable. Here we show that PTTG disruption in mice (PTTG-/-) severely impairs glucose homeostasis leading to diabetes during late adulthood, especially in males associated with nonautoimmune insulinopenia and reversed alphabeta cell ratio. Islet beta cell mass in PTTG-/- mice was already diminished before development of frank diabetes and only increased minimally during growth. BrdUrd incorporation of islet cells in PTTG-null mice was approximately 65% lower (P < 0.005) than in the WT pancreas, whereas apoptosis rates were similar. PTTG-/- beta cells had pleiotropic nuclei, suggesting defects in cell division. The results indicated that securin is indispensable for normal pancreatic beta cell proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.