ArticleProceedings of the National Academy of Sciences of the United States of America2003
An approach to electrical modeling of single and multiple cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Review
- 2D electrical admittance lattice model of biological cellular system for modeling electroporation.Biophysical journal · 2024Article
- Dielectric Dispersion Modulated Sensing of Yeast Suspension Electroporation.Sensors (Basel, Switzerland) · 2022Article
- Review
- Article
- Proximity-induced electrodeformation and membrane capacitance coupling between cells.European biophysics journal : EBJ · 2021Article
- Electroporation safety factor of 300 nanosecond and 10 millisecond defibrillation in Langendorff-perfused rabbit hearts.PloS one · 2021Article
- Nanosecond pulsed electric fields modulate the expression of the astaxanthin biosynthesis genes psy, crtR-b and bkt 1 in Haematococcus pluvialis.Scientific reports · 2020Article
- A General Theoretical Framework to Study the Influence of Electrical Fields on Mesenchymal Stem Cells.Frontiers in bioengineering and biotechnology · 2020Article
- Wide-area low-energy surface stimulation of large mammalian ventricular tissue.Scientific reports · 2019Article
- Excitation of murine cardiac myocytes by nanosecond pulsed electric field.Journal of cardiovascular electrophysiology · 2019Article
- A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes.Sensors (Basel, Switzerland) · 2018Article
- Microphysiological flux balance platform unravels the dynamics of drug induced steatosis.Lab on a chip · 2018Article
- Article
- Low-energy defibrillation with nanosecond electric shocks.Cardiovascular research · 2017Article
- Irreversible electroporation inhibits pro-cancer inflammatory signaling in triple negative breast cancer cells.Bioelectrochemistry (Amsterdam, Netherlands) · 2017Article
- Modeling of Transmembrane Potential in Realistic Multicellular Structures before Electroporation.Biophysical journal · 2016Article
- An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields.International journal of environmental research and public health · 2016Review
- A Microdosimetric Study of Electropulsation on Multiple Realistically Shaped Cells: Effect of Neighbours.The Journal of membrane biology · 2016Article
- Effects of Nanosecond Pulsed Electric Fields on the Intracellular Function of HeLa Cells As Revealed by NADH Autofluorescence Microscopy.ACS omega · 2016Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous theoretical approaches to understanding effects of electric fields on cells have used partial differential equations such as Laplace's equation and cell models with simple shapes. Here we describe a transport lattice method illustrated by a didactic multicellular system model with irregular shapes. Each elementary membrane region includes local models for passive membrane resistance and capacitance, nonlinear active sources of the resting potential, and a hysteretic model of electroporation. Field amplification through current or voltage concentration changes with frequency, exhibiting significant spatial heterogeneity until the microwave range is reached, where cellular structure becomes almost "electrically invisible." In the time domain, membrane electroporation exhibits significant heterogeneity but occurs mostly at invaginations and cell layers with tight junctions. Such results involve emergent behavior and emphasize the importance of using multicellular models for understanding tissue-level electric field effects in higher organisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.