ArticleProceedings of the National Academy of Sciences of the United States of America2003
Transcriptional network controlled by the trithorax-group gene ash2 in Drosophila melanogaster.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Loss-of-function in RBBP5 results in a syndromic neurodevelopmental disorder associated with microcephaly.Genetics in medicine : official journal of the American College of Medical Genetics · 2024Article
- A high-quality Ixodes scapularis genome advances tick science.Nature genetics · 2023Article
- Absence of canonical marks of active chromatin in developmentally regulated genes.Nature genetics · 2015Article
- The Drosophila wings apart gene anchors a novel, evolutionarily conserved pathway of neuromuscular development.Genetics · 2013Article
- Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr.Molecular biology of the cell · 2013Article
- Genome-wide chromatin occupancy analysis reveals a role for ASH2 in transcriptional pausing.Nucleic acids research · 2011Article
- Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs.BMC developmental biology · 2010Article
- Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human.The FEBS journal · 2010Review
- Mating induces an immune response and developmental switch in the Drosophila oviduct.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila.Genome biology · 2008Article
- Functional dissection of the ash2 and ash1 transcriptomes provides insights into the transcriptional basis of wing phenotypes and reveals conserved protein interactions.Genome biology · 2007Article
- Development of a microscopic platform for real-time monitoring of biomolecular interactions.Genome research · 2006Article
- Article
- Transcriptional signature of an adult brain tumor in Drosophila.BMC genomics · 2004Article
- ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia.British journal of cancer · 2004Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor absent, small, or homeotic discs 2 (ash2) gene is a member of the trithorax group of positive regulators of homeotic genes. Mutant alleles for ash2 are larvalpupal lethals and display imaginal disc and brain abnormalities. The allele used in this study is a true mutant for the trithorax function and lacks the longest transcript present in wild-type flies. In an attempt to identify gene targets of ash2, we have performed an expression analysis by using cDNA microarrays. Genes involved in cell cycle, cell proliferation, and cell adhesion are among these targets, and some of them are validated by functional and expression studies. Even though trithorax proteins act by modulating chromatin structure at particular chromosomal locations, evidence of physical aggregation of ash2-regulated genes has not been found. This work represents the first microarray analysis, to our knowledge, of a trithorax-group gene.
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