ArticleThe Journal of physiology2003
Modulation of human ether-à-go-go-related K+ (HERG) channel inactivation by Cs+ and K+.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Recording ten-fold larger IFrontiers in physiology · 2024Article
- A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient KMolecular pharmacology · 2022Article
- Bidirectional flow of the funny current (IProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Effects of Antiarrhythmic Drugs on hERG Gating in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1.Frontiers in pharmacology · 2021Article
- KNeuroscience · 2020Article
- Modulation of Ether-à-Go-Go Related Gene (ERG) Current Governs Intrinsic Persistent Activity in Rodent Neocortical Pyramidal Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- An Introduction to Computational Modeling of Cardiac Electrophysiology and Arrhythmogenicity.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Article
- Role of the activation gate in determining the extracellular potassium dependency of block of HERG by trapped drugs.Channels (Austin, Tex.) · 2013Article
- Article
- Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant.Biophysical journal · 2011Article
- Ceramide modulates HERG potassium channel gating by translocation into lipid rafts.American journal of physiology. Cell physiology · 2010Article
- State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy.American journal of physiology. Cell physiology · 2009Article
- Na+ permeation and block of hERG potassium channels.The Journal of general physiology · 2006Article
- Modulation of HERG channel inactivation by external cations.European biophysics journal : EBJ · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unlike many other native and cloned K+ channels, human ether-à-go-go-related K+ (HERG) channels show significant Cs+ permeability with a PCs/PK (the permeability of Cs+ relative to that of K+) of 0.36 +/- 0.03 (n = 10). Here, we find that raising the concentration of external Cs+ (Cs+o) dramatically slows HERG channel inactivation without affecting activation. Replacement of 5 mM K+o by 135 mM Cs+o increased both inactivation and recovery time constants and shifted the mid-point of the steady-state inactivation curve by 25 mV in the depolarized direction (n = 6, P < 0.01). Raising [Cs+]o also modulated the voltage sensitivity of inactivation gating. With 130 mM Cs+i and 135 mM NMDG+o, the inactivation time constant decreased e-fold per 47.5 +/- 1.1 mV (n = 5), and when 20 mM Cs+ was added to the bath solution, the inactivation time constant decreased e-fold per 20.6 +/- 1.3 mV (n = 5, P < 0.01). A quantitative analysis suggests that Cs+o binds to a site in the pore that is influenced by the transmembrane electrical field, so that Cs+o-induced slowing of HERG inactivation is less prominent at strong depolarizations. K+o has effects that are similar to Cs+o and their effects were additive, suggesting Cs+o and K+o may share a common mechanism of action. The strong effects of Cs+ on inactivation but not on activation highlight the importance of ion and channel interactions during the onset of inactivation in the HERG channel.
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