ArticleHuman genetics2003
Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p.
Article in Human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Children's perceptions about medicines: individual differences and taste.BMC pediatrics · 2015Trial
- Validation of edible taste strips for assessing PROP taste perception.Chemical senses · 2013Trial
- Responsiveness to 6-n-propylthiouracil (PROP) is associated with salivary levels of two specific basic proline-rich proteins in humans.PloS one · 2012Trial
- Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark.PloS one · 2011Trial
- Phenome-wide investigation of dietary and health outcomes associated with bitter taste receptor gene TAS2R38.European journal of nutrition · 2025Article
- Automated identification of the genetic variants of TAS2R38 bitter taste receptor with supervised learning.Computational and structural biotechnology journal · 2023Article
- Association of phenylthiocarbamide perception with anthropometric variables and intake and liking for bitter vegetables.Genes & nutrition · 2022Article
- Automated Classification of 6-n-Propylthiouracil Taster Status with Machine Learning.Nutrients · 2022Article
- Article
- The roles of genes in the bitter taste.AIMS genetics · 2019Review
- Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste.BMC genomics · 2018Article
- Taste Perception of Antidesma bunius Fruit and Its Relationships to Bitter Taste Receptor Gene Haplotypes.Chemical senses · 2018Article
- Review
- Use of Adult Sensory Panel to Study Individual Differences in the Palatability of a Pediatric HIV Treatment Drug.Clinical therapeutics · 2017Observational
- An automated system for the objective evaluation of human gustatory sensitivity using tongue biopotential recordings.PloS one · 2017Article
- Is the Association Between Sweet and Bitter Perception due to Genetic Variation?Chemical senses · 2016Article
- Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal.Scientific reports · 2016Article
- Genetic Vulnerability to Menthol Cigarette Preference in Women.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015Article
- Article
- Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The ability to taste phenylthiocarbamide (PTC) shows complex inheritance in humans. We obtained a quantitative measure of PTC tasting ability in 267 members of 26 large three-generation families that were part of a set of CEPH families that had been used for genetic mapping. Significant bimodality was found for the distribution of age and gender adjusted scores (P<0.001), with estimated means of 3.16 (SD=1.80) and 9.26 (SD=1.54). Using the extensive genotyping available in these families from the genetic mapping efforts, we performed a genome scan by using 1324 markers with an average spacing of 4 cM. Analyses were first carried out with a recessive genetic model that has traditionally been assumed for the trait, and a threshold score of 8.0 delineating tasters from non-tasters. In this qualitative analysis, the maximum genome-wide lod score was 4.74 at 246 cM on chromosome 7; 17 families showed segregation of the dichotomous PTC phenotype. No other lod scores were significant; the next highest score was on chromosome 10 (lod=1.64 at 85 cM), followed by chromosome 3 (lod=1.29 at 267 cM). Because PTC taste ability exhibited substantial quantitative variation, the quantitative trait was also analyzed by using a variance components approach in SOLAR. The maximum quantitative genome-wide lod score was 8.85 at 246 cM on chromosome 7. Evidence for other possible quantitative loci was found on chromosomes 1 (lod=2.31 at 344 cM) and 16 (lod=2.01 at 14 cM). A subsequent two-locus whole-genome scan conditional on the chromosome 7 quantitative trait locus identified the chromosome 16 locus (two-locus lod=3.33 at 14 cM).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.