ReviewEndocrine2002
Cre/lox: one more step in the taming of the genome.
Review in Endocrine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- The contradictory role of androgens in cutaneous and major burn wound healing.Burns & trauma · 2021Review
- Lox'd in translation: contradictions in the nomenclature surrounding common lox-site mutants and their implications in experiments.Microbiology (Reading, England) · 2021Article
- Genome Editing Fidelity in the Context of DNA Sequence and Chromatin Structure.Frontiers in cell and developmental biology · 2020Review
- Gene stacking by recombinases.Plant biotechnology journal · 2016Review
- Emerging Technologies to Create Inducible and Genetically Defined Porcine Cancer Models.Frontiers in genetics · 2016Review
- Viral transduction of primary Schwann cells using a Cre-lox system to regulate GDNF expression.Biotechnology and bioengineering · 2014Article
- Advancing the discovery of medications for autism spectrum disorder using new technologies to reveal social brain circuitry in rodents.Psychopharmacology · 2014Review
- Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease.American journal of physiology. Gastrointestinal and liver physiology · 2012Review
- A system for the targeted amplification of bacterial gene clusters multiplies antibiotic yield in Streptomyces coelicolor.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Targeted protein depletion in Saccharomyces cerevisiae by activation of a bidirectional degron.BMC systems biology · 2010Article
- Cre-ating Ways to Serotonin.Frontiers in neuroscience · 2010Article
- Efficient protein depletion by genetically controlled deprotection of a dormant N-degron.Molecular systems biology · 2009Article
- Myc stimulates B lymphocyte differentiation and amplifies calcium signaling.The Journal of cell biology · 2007Article
- Cre reconstitution allows for DNA recombination selectively in dual-marker-expressing cells in transgenic mice.Nucleic acids research · 2007Article
- Towards synthesis of a minimal cell.Molecular systems biology · 2006Review
- A rapid and efficient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system.Nucleic acids research · 2004Article
- Propagation of infectious human papillomavirus type 16 by using an adenovirus and Cre/LoxP mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Using the cre-lox recombination system to assess functional impairment caused by amino acid substitutions in yeast proteins.Biological procedures onlineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cre recombinase has become an important tool in the precise manipulation of the genome, and its adoption has led to the development of increasingly accurate mouse models for the understanding of gene function. Although much of current work exploits the alacrity and precision with which Cre catalyzes excisive DNA recombination, Cre also is adept at the insertion of heterologous DNA into the genome. The precision and efficiency with which Cre can target DNA to a predesignated locus in the genome promises to facilitate understanding of mutant genes and allelic variants in their natural chromosomal context.
Indexed as
Identifiers
12624421What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.