ArticleJournal of clinical microbiology2003
Bacillus anthracis virulence in Guinea pigs vaccinated with anthrax vaccine adsorbed is linked to plasmid quantities and clonality.
Article in Journal of clinical microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Transcriptome analysis unveils survival strategies of Streptococcus parauberis against fish serum.PloS one · 2021Article
- Practical and effective diagnosis of animal anthrax in endemic low-resource settings.PLoS neglected tropical diseases · 2020Article
- Review: The risk of contracting anthrax from spore-contaminated soil - A military medical perspective.European journal of microbiology & immunology · 2020Article
- Rapid Detection of Bacillus anthracis Bloodstream Infections by Use of a Novel Assay in the GeneXpert System.Journal of clinical microbiology · 2017Article
- In silico and in vitro evaluation of PCR-based assays for the detection of Bacillus anthracis chromosomal signature sequences.Virulence · 2013Article
- Two independent replicons can support replication of the anthrax toxin-encoding plasmid pXO1 of Bacillus anthracis.Plasmid · 2012Article
- Development and comparison of two assay formats for parallel detection of four biothreat pathogens by using suspension microarrays.PloS one · 2012Article
- Bovine Bacillus anthracis in Cameroon.Applied and environmental microbiology · 2011Article
- The phenotypic and genotypic characterization of Bacillus anthracis isolates from Iran.Tropical animal health and production · 2011Article
- Reliable detection of Bacillus anthracis, Francisella tularensis and Yersinia pestis by using multiplex qPCR including internal controls for nucleic acid extraction and amplification.BMC microbiology · 2010Article
- Structure and complexity of a bacterial transcriptome.Journal of bacteriology · 2009Article
- Efficacy of a vaccine based on protective antigen and killed spores against experimental inhalational anthrax.Infection and immunity · 2009Article
- Article
- Discriminating virulence mechanisms among Bacillus anthracis strains by using a murine subcutaneous infection model.Infection and immunity · 2009Article
- Gamma irradiation can be used to inactivate Bacillus anthracis spores without compromising the sensitivity of diagnostic assays.Applied and environmental microbiology · 2008Article
- Transcriptional profiling of murine organ genes in response to infection with Bacillus anthracis Ames spores.Microbial pathogenesis · 2008Article
- Geographical distribution of genotypic and phenotypic markers among Bacillus anthracis isolates and related species by historical movement and horizontal transfer.Folia microbiologica · 2008Article
- Simultaneous real-time PCR detection of Bacillus anthracis, Francisella tularensis and Yersinia pestis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2007Article
- High throughput screening for spores and vegetative forms of pathogenic B. anthracis by an internally controlled real-time PCR assay with automated DNA preparation.Medical microbiology and immunology · 2007Article
- Complete sequence analysis of novel plasmids from emetic and periodontal Bacillus cereus isolates reveals a common evolutionary history among the B. cereus-group plasmids, including Bacillus anthracis pXO1.Journal of bacteriology · 2007Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacillus anthracis is a bacterial pathogen of great importance, both historically and in the present. This study presents data collected from several investigations and indicates that B. anthracis virulence is associated with the clonality and virulence of plasmids pXO1 and pXO2. Guinea pigs vaccinated with Anthrax Vaccine Adsorbed were challenged with 20 B. anthracis isolates representative of worldwide genetic diversity. These same isolates were characterized with respect to plasmid copy number by using a novel method of quantitative PCR developed for rapid and efficient detection of B. anthracis from environmental samples. We found that the copy numbers for both pXO1 and pXO2 differed from those in previously published reports. By combining the data on survival, plasmid copy numbers, and clonality, we developed a model predicting virulence. This model was validated by using a randomly chosen set of 12 additional B. anthracis isolates. Results from this study will be helpful in future efforts to elucidate the basis for variation in the virulence of this important pathogen.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.