Evidence map›Paper›PMID 12624040›Full record

ArticleJournal of clinical microbiology2003

In vitro susceptibility testing of Aspergillus spp.: comparison of Etest and reference microdilution methods for determining voriconazole and itraconazole MICs.

J B Pfaller, S A Messer, R J Hollis, D J Diekema, M A Pfaller

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 80 citations in OpenAlex.

  1. Investigation of azole resistance inJournal of medical microbiology · 2026
    Article
  2. Azole Resistance inJournal of fungi (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Importance of theJournal of fungi (Basel, Switzerland) · 2024
    Article
  5. Review
  6. Article
  7. Antifungal Susceptibility Testing: Current Approaches.Clinical microbiology reviews · 2020
    Review
  8. Azole resistantClinical microbiology newsletter · 2020
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Michael A. Pfaller, M.D.Journal of clinical microbiology · 2013
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

J B PfallerDepartments of Pathology. Medicine. Epidemiology, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa 52242, USA.
S A Messer
R J Hollis
D J Diekema
M A Pfaller
University of Iowa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The performance of the Etest for voriconazole and for itraconazole susceptibility testing of 376 isolates of Aspergillus spp. was assessed in comparison with the National Committee for Clinical Laboratory Standards (NCCLS) proposed standard microdilution broth method. The NCCLS method employed RPMI 1640 broth medium, and MICs were read after incubation for 48 h at 35 degrees C. Etest MICs were determined with RPMI agar containing 2% glucose and were read after incubation for 48 h at 35 degrees C. The isolates included A. fumigatus, A. flavus, A. niger, A. terreus, A. versicolor, A. glaucus, A. nidulans, A. ustus, and A. sydowii. Overall agreement percentages between the Etest and microdilution MICs were 97.6% for voriconazole and 95.8% for itraconazole. Where a discrepancy was observed between Etest and the reference method, the Etest tended to give lower values with voriconazole and higher values with itraconazole. The Etest method using RPMI agar appears to be a useful method for determining the voriconazole and itraconazole susceptibilities of Aspergillus spp.

Indexed as

Antifungal AgentsAspergillusHumansItraconazoleMicrobial Sensitivity TestsMicrobiological TechniquesPyrimidinesTriazolesVoriconazoleAntifungal AgentsItraconazolePyrimidinesTriazolesVoriconazole

Identifiers

PMID12624040
PMCPMC150323
OpenAlexW2122157744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.