ArticleJournal of clinical microbiology2003
Epidemiologic analysis of invasive and noninvasive group a streptococcal isolates in Hong Kong.
Article in Journal of clinical microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 62 citations in OpenAlex.
- The burden of group AiScience · 2025Review
- Beta-Haemolytic Group A, C and G Streptococcal Infections in Southern Hungary: A 10-Year Population-Based Retrospective Survey (2008-2017) and a Review of the Literature.Infection and drug resistance · 2020Article
- Direct bacterial identification in positive blood cultures by use of two commercial matrix-assisted laser desorption ionization-time of flight mass spectrometry systems.Journal of clinical microbiology · 2013Article
- Scarlet fever epidemic, Hong Kong, 2011.Emerging infectious diseases · 2012Article
- Progress in the development of effective vaccines to prevent selected gram-positive bacterial infections.The American journal of the medical sciences · 2010Review
- Comparative analysis of emm type pattern of Group A Streptococcus throat and skin isolates from India and their association with closely related SIC, a streptococcal virulence factor.BMC microbiology · 2008Article
- Molecular epidemiology of the sil streptococcal invasive locus in group A streptococci causing invasive infections in French children.Journal of clinical microbiology · 2007Article
- Group A streptococci from invasive-disease episodes in Poland are remarkably divergent at the molecular level.Journal of clinical microbiology · 2006Article
- M protein gene (emm type) analysis of group A beta-hemolytic streptococci from Ethiopia reveals unique patterns.Journal of clinical microbiology · 2005Article
- Identity and prevalence of multilocus sequence typing-defined clones of group A streptococci within a hospital setting.Journal of clinical microbiology · 2005Article
- Phenotypic and molecular characterization of erythromycin resistance in four isolates of Streptococcus-like gram-positive cocci causing bacteremia.Journal of clinical microbiology · 2004Article
- Epidemiological features of invasive and noninvasive group A streptococcal disease in the Netherlands, 1992-1996.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2004Article
- Clinical and molecular epidemiology of erythromycin-resistant beta-hemolytic lancefield group G streptococci causing bacteremia.Journal of clinical microbiology · 2003Article
- emm typing of M nontypeable invasive group A streptococcal isolates in Israel.Journal of clinical microbiology · 2003Article
- Molecular characterization of a strain of group a streptococcus isolated from a patient with a psoas abscess.Journal of clinical microbiology · 2003Article
- Prevalence of Beta-Hemolytic Streptococci Groups A, C, and G in Patients with Acute Pharyngitis.Journal of laboratory physiciansArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the mid-1980s, there has been a resurgence of severe forms of invasive group A streptococcal (GAS) disease in many Western countries. In Hong Kong, a similar increase has also been observed in recent years. One hundred seven GAS isolates collected from 1995 to 1998 from individuals with necrotizing fasciitis, toxic shock syndrome, meningitis, or other type of bacteremic sepsis (invasive group, n = 24) as well as from individuals with minor skin and throat infections (noninvasive group, n = 83) were characterized through serologic and/or emm sequence typing. Thirty-two M protein gene sequence types were identified. Types M1, M4, and M12 were the most prevalent in both the invasive group and the noninvasive group; together they accounted for 70.8 and 37.3% of the isolates, respectively. No clear pattern of skin and throat infection M types was observed. Type M1 was overrepresented in the invasive and pharyngeal isolates. The same pulsed-field gel electrophoresis pattern was shared by most invasive and all pharyngeal M1 isolates. Overall, resistance to erythromycin (32%) and tetracycline (53%) was high, but M1 isolates were significantly less likely to have resistance to either antimicrobial agent than non-M1 isolates. One novel emm sequence type, stHK, was identified in an isolate from a patient with necrotizing fasciitis. Minor emm gene sequence alterations were noted for 31 isolates, and for 13 of these isolates, deletion, insertion, or point mutations were seen in the hypervariable 50 N-terminal residues.
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