Trial reportAtencion primaria2003
[Effectiveness of combined therapy at set doses in a cohort of hypertense patients not controlled by single therapy].
Trial report in Atencion primaria, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effectiveness of the fixed dose of a lisinopril-hydrochlorothiazide combination treatment in the control of blood pressure, in poorly controlled high blood pressure people, treated with monotherapy.Design. Prospective observational study.Setting. Primary care frame.Participants. 931 patients (56.7% women) with an average age of 62.0+/-3 years, were included by 199 primary care physicians. 915 patients (98%) ended the study and finally they were included for the statistical analysis. MAIN MEASUREMENTS: OMS/SIH recommendations on blood pressure measurement and diagnose of poor control were followed. Pulse pressure, body mass index and basic clinical analyses were assessed. Four continuation visits were made during six months.
resultsLisinopril-hidrochlorothiazide (20/12.5 mg) reduced significantly SBP (24.6 +/- 3.5 mm Hg) and DBP (14,3 +/- 0.7 mm Hg) (P<.001). Blood pressure control was only influenced by age (OR, 0.81; 95% CI, 0.71-0.92; P=.001). Pulse pressure was reduced in 10.4 +/- 4.3 mm Hg (P<.001). After 24 weeks of treatment, glycemic and lipidic profiles showed an improvement, as well as HbA1c in diabetic people.
conclusionsIn Primary care, a 52.8% of poorly controlled with monotherapy high blood pressure people were controlled by a combination of lisinopril-hydrochlorothiazide (20/12.5 mg). In addition, pulse pressure was decreased and both lipid and glucose blood profiles improved.
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