ReviewInternational journal of gastrointestinal cancer2002
TGFbeta-induced fibrogenesis of the pancreas.
Review in International journal of gastrointestinal cancer, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- ROS and TGFβ: from pancreatic tumour growth to metastasis.Journal of experimental & clinical cancer research : CR · 2021Review
- NADPH oxidase 1 mediates caerulein-induced pancreatic fibrosis in chronic pancreatitis.Free radical biology & medicine · 2020Article
- Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis.Molecular cancer · 2019Review
- The Toll-like receptor 4 antagonist TAK-242 protects against chronic pancreatitis in rats.Molecular medicine reports · 2017Article
- Hedgehog Signaling in Pancreatic Fibrosis and Cancer.Medicine · 2016Review
- Halofuginone for fibrosis, regeneration and cancer in the gastrointestinal tract.World journal of gastroenterology · 2014Review
- Inhibitory effects of prostaglandin E2 on collagen synthesis and cell proliferation in human stellate cells from pancreatic head adenocarcinoma.BMC cancer · 2014Article
- Carcinogenesis of pancreatic adenocarcinoma: precursor lesions.International journal of molecular sciences · 2013Review
- Prolonged high fat/alcohol exposure increases TRPV4 and its functional responses in pancreatic stellate cells.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Cerulein-induced chronic pancreatitis does not require intra-acinar activation of trypsinogen in mice.Gastroenterology · 2013Article
- Article
- Matrix metalloproteinase-9, transforming growth factor-β1, and tumor necrosis factor-α plasma levels in chronic pancreatitis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2013Article
- The reactive stroma microenvironment and prostate cancer progression.Endocrine-related cancer · 2012Review
- The value of thioredoxin family proteins and proliferation markers in dysplastic and malignant gallbladders in patients with primary sclerosing cholangitis.Digestive diseases and sciences · 2012Article
- Plasma TGF-β1, MMP-1 and MMP-3 Levels in Chronic Pancreatitis.Indian journal of clinical biochemistry : IJCB · 2012Article
- Therapeutic potential of perineural invasion, hypoxia and desmoplasia in pancreatic cancer.Current pharmaceutical design · 2012Review
- Article
- Divalent cations modulate alpha2beta1 integrin-mediated malignancy in a novel 3-dimensional in vitro model of pancreatic cancer.Pancreas · 2010Article
- Protective role of angiotensin II type 2 receptor signaling in a mouse model of pancreatic fibrosis.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biological cause of fibrosis is the accumulation of excessive amounts of extracellular matrix (ECM) which leads to tissue dysfunction and organ failure. A strong correlation can be found between pancreatic diseases and fibrotic processes, in particular chronic pancreatitis and pancreatic cancer. There is growing evidence that pancreatic fibrosis represents a dysregulation of the normal repair processes after injury. This concept is based on the findings that fibrosis and tissue repair involve similar biological reactions regulated by the same group of molecules. The best characterized example for these regulatory molecules are the members of the transforming growth factor beta family (TGFbeta). TGFbeta1 represents the prototype of this family of highly similar growth factors, with the unique ability to stimulate the expression and deposition of extracellular matrix and to inhibit its degradation. Growth factor-induced fibrotic events are targeted by a myofibroblast-like cell called pancreatic stellate cell (PSC). These cells show enhanced expression of all-important ECM proteins after TGFbeta stimulation including collagen, fibronectin and proteoglycans. At the same time TGFbeta inhibits the degradation of ECM by blocking the secretion of proteases and stimulating the production of naturally occurring protease inhibitors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.