ReviewBone marrow transplantation2003
Clinical application of hematopoietic progenitor cell expansion: current status and future prospects.
Review in Bone marrow transplantation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Synergistic effect and molecular mechanism of nicotinamide and UM171 inRegenerative therapy · 2024Article
- Engineered Tissue Models to Replicate Dynamic Interactions within the Hematopoietic Stem Cell Niche.Advanced healthcare materials · 2022Review
- Distinguishing autocrine and paracrine signals in hematopoietic stem cell culture using a biofunctional microcavity platform.Scientific reports · 2016Article
- Hematopoetic stem cell transplantation in children.Turk pediatri arsivi · 2014Review
- Recombinant IL-7/HGFβ efficiently induces transplantable murine hematopoietic stem cells.The Journal of clinical investigation · 2012Article
- Inhibition of p38 MAPK activity promotes ex vivo expansion of human cord blood hematopoietic stem cells.Annals of hematology · 2012Article
- Granulocyte-derived cationic Peptide enhances homing and engraftment of bone marrow stem cells after transplantation.Laboratory animal research · 2011Article
- Cord blood stem cell expansion is permissive to epigenetic regulation and environmental cues.Experimental hematology · 2009Article
- Effect of ex vivo culture of CD34+ bone marrow cells on immune reconstitution of XSCID dogs following allogeneic bone marrow transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2009Article
- Ex vivo expansion of CD34+ and T and NK cells from umbilical cord blood for leukemic BALB/C nude mouse transplantation.International journal of hematology · 2008Article
- Expansion of human hematopoietic stem cells for transplantation: trends and perspectives.Cytotechnology · 2008Article
- Adult umbilical cord blood transplantation: a comprehensive review.Bone marrow transplantation · 2006Review
- Lymphokine activated killer cells from umbilical cord blood show higher antitumor effect against anaplastic astrocytoma cell line (U87) and medulloblastoma cell line (TE671) than lymphokine activated killer cells from peripheral blood.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the past decade, we have witnessed significant advances in ex vivo hematopoietic stem cell culture expansion, progressing to the point where clinical trials are being designed and conducted. Preclinical milestone investigations provided data to enable expansion of portions of hematopoietic grafts in a clinical setting, indicating safety and feasibility of this approach. Data derived from current clinical trials indicate successful reconstitution of hematopoiesis after myeloablative chemoradiotherapy using infusion of ex vivo-expanded perfusion cultures. Future avenues of exploration will focus upon refining preclinical and clinical studies in which cocktails of available cytokines, novel molecules and sophisticated expansion systems will explore expansion of blood, marrow and umbilical cord blood cells.
Indexed as
Identifiers
12621458What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.