ArticleApplied and environmental microbiology2003
Comparative genomic analyses of the vibrio pathogenicity island and cholera toxin prophage regions in nonepidemic serogroup strains of Vibrio cholerae.
Article in Applied and environmental microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 64 citations in OpenAlex.
- Diversity and Complexity of CTXΦ and Pre-CTXΦ Families inMicroorganisms · 2024Article
- Genomic epidemiology of Vibrio cholerae reveals the regional and global spread of two epidemic non-toxigenic lineages.PLoS neglected tropical diseases · 2020Article
- Vibrio Pathogenicity Island-1: The Master Determinant of Cholera Pathogenesis.Frontiers in cellular and infection microbiology · 2020Review
- Application of filamentous phages in environment: A tectonic shift in the science and practice of ecorestoration.Ecology and evolution · 2019Article
- Excisionase in Pf filamentous prophage controls lysis-lysogeny decision-making in Pseudomonas aeruginosa.Molecular microbiology · 2019Article
- Limpet (Frontiers in public health · 2018Article
- A genomic island in Vibrio cholerae with VPI-1 site-specific recombination characteristics contains CRISPR-Cas and type VI secretion modules.Scientific reports · 2016Article
- Genetic relatedness of selected clinical Vibrio cholerae O139 isolates from the southern coastal area of China over a 20-year period.Epidemiology and infection · 2016Article
- Long 5' untranslated regions regulate the RNA stability of the deep-sea filamentous phage SW1.Scientific reports · 2016Article
- Characterization of Five Novel Brevibacillus Bacteriophages and Genomic Comparison of Brevibacillus Phages.PloS one · 2016Article
- The Hybrid Pre-CTXΦ-RS1 Prophage Genome and Its Regulatory Function in Environmental Vibrio cholerae O1 Strains.Applied and environmental microbiology · 2015Article
- Survival and proliferation of the lysogenic bacteriophage CTXΦ in Vibrio cholerae.Virologica Sinica · 2015Review
- Article
- A molecular surveillance reveals the prevalence of Vibrio cholerae O139 isolates in China from 1993 to 2012.Journal of clinical microbiology · 2014Article
- Genomic science in understanding cholera outbreaks and evolution of Vibrio cholerae as a human pathogen.Current topics in microbiology and immunology · 2014Review
- Population structure and evolution of non-O1/non-O139 Vibrio cholerae by multilocus sequence typing.PloS one · 2013Article
- In silico analyses of primers used to detect the pathogenicity genes of Vibrio cholerae.Microbes and environments · 2012Article
- Amplified fragment length polymorphism of clinical and environmental Vibrio cholerae from a freshwater environment in a cholera-endemic area, India.BMC infectious diseases · 2011Article
- Article
- Structure, function, and evolution of the Thiomonas spp. genome.PLoS genetics · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two major virulence factors are associated with epidemic strains (O1 and O139 serogroups) of Vibrio cholerae: cholera toxin encoded by the ctxAB genes and toxin-coregulated pilus encoded by the tcpA gene. The ctx genes reside in the genome of a filamentous phage (CTXphi), and the tcpA gene resides in a vibrio pathogenicity island (VPI) which has also been proposed to be a filamentous phage designated VPIphi. In order to determine the prevalence of horizontal transfer of VPI and CTXphi among nonepidemic (non-O1 and non-O139 serogroups) V. cholerae, 300 strains of both clinical and environmental origin were screened for the presence of tcpA and ctxAB. In this paper, we present the comparative genetic analyses of 11 nonepidemic serogroup strains which carry the VPI cluster. Seven of the 11 VPI(+) strains have also acquired the CTXphi. Multilocus sequence typing and restriction fragment length polymorphism analyses of the VPI and CTXphi prophage regions revealed that the non-O1 and non-O139 strains were genetically diverse and clustered in lineages distinct from that of the epidemic strains. The left end of the VPI in the non-O1 and non-O139 strains exhibited extensive DNA rearrangements. In addition, several CTXphi prophage types characterized by novel repressor (rstR) and ctxAB genes and VPIs with novel tcpA genes were found in these strains. These data suggest that the potentially pathogenic, nonepidemic, non-O1 and non-O139 strains identified in our study most likely evolved by sequential horizontal acquisition of the VPI and CTXphi independently rather than by exchange of O-antigen biosynthesis regions in an existing epidemic strain.
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