ArticleApplied and environmental microbiology2003
Transcriptional cross-regulation of the catechol and protocatechuate branches of the beta-ketoadipate pathway contributes to carbon source-dependent expression of the Acinetobacter sp. strain ADP1 pobA gene.
Article in Applied and environmental microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- Cis,cis-muconic acid production from lignin related molecules byAcinetobacter baylyi ADP1.Microbial cell factories · 2025Article
- Elucidation of 4-Hydroxybenzoic Acid Catabolic Pathways inInternational journal of molecular sciences · 2024Article
- Article
- Deciphering the transcriptional regulation of the catabolism of lignin-derived aromatics in Rhodococcus opacus PD630.Communications biology · 2022Article
- Development of a genetic toolset for the highly engineerable and metabolically versatile Acinetobacter baylyi ADP1.Nucleic acids research · 2020Article
- Removal of aromatic inhibitors produced from lignocellulosic hydrolysates byBiotechnology for biofuels · 2019Article
- Corynebacterium Cell Factory Design and Culture Process Optimization for Muconic Acid Biosynthesis.Scientific reports · 2018Article
- Genomics and biochemistry investigation on the metabolic pathway of milled wood and alkali lignin-derived aromatic metabolites ofBiotechnology for biofuels · 2018Article
- Lighting up yeast cell factories by transcription factor-based biosensors.FEMS yeast research · 2017Article
- Hierarchy of Carbon Source Utilization in Soil Bacteria: Hegemonic Preference for Benzoate in Complex Aromatic Compound Mixtures Degraded by Cupriavidus pinatubonensis Strain JMP134.Applied and environmental microbiology · 2015Article
- Genomic and metabolic analysis of fluoranthene degradation pathway in Celeribacter indicus P73T.Scientific reports · 2015Article
- Benzoate mediates the simultaneous repression of anaerobic 4-methylbenzoate and succinate utilization in Magnetospirillum sp. strain pMbN1.BMC microbiology · 2014Article
- Novel metabolic features inMetabolomics : Official journal of the Metabolomic Society · 2014Article
- Simultaneous catabolism of plant-derived aromatic compounds results in enhanced growth for members of the Roseobacter lineage.Applied and environmental microbiology · 2013Article
- Study of PcaV from Streptomyces coelicolor yields new insights into ligand-responsive MarR family transcription factors.Nucleic acids research · 2013Article
- Bacterial degradation of benzoate: cross-regulation between aerobic and anaerobic pathways.The Journal of biological chemistry · 2012Article
- PcaO positively regulates pcaHG of the beta-ketoadipate pathway in Corynebacterium glutamicum.Journal of bacteriology · 2010Article
- Role of Acinetobacter baylyi Crc in catabolite repression of enzymes for aromatic compound catabolism.Journal of bacteriology · 2009Article
- Oligomerization of BenM, a LysR-type transcriptional regulator: structural basis for the aggregation of proteins in this family.Acta crystallographica. Section F, Structural biology and crystallization communications · 2007Article
- Multiple-level regulation of genes for protocatechuate degradation in Acinetobacter baylyi includes cross-regulation.Applied and environmental microbiology · 2007Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Transcriptional control of carbon source preferences by Acinetobacter sp. strain ADP1 was assessed with a pobA::lacZ fusion during growth on alternative substrates. The pobA-encoded enzyme catalyzes the first step in the degradation of 4-hydroxybenzoate, a compound consumed rapidly as a sole carbon source. If additional aromatic carbon sources are available, 4-hydroxybenzoate consumption is inhibited by unknown mechanisms. As reported here, during growth on aromatic substrates, pobA was not expressed despite the presence of 4-hydroxybenzoate, an inducer that normally causes the PobR regulator to activate pobA transcription. Growth on organic acids such as succinate, fumarate, and acetate allowed higher levels of pobA expression. In each case, pobA expression increased at the end of the exponential growth phase. Complex transcriptional regulation controlled 4-hydroxybenzoate catabolism in multisubstrate environments. Additional studies focused on the wild-type preference for benzoate consumption prior to 4-hydroxybenzoate consumption. These compounds are degraded via the catechol and protocatechuate branches of the beta-ketoadipate pathway, respectively. Here, mutants were characterized that degraded benzoate and 4-hydroxybenzoate concurrently. These mutants lacked the BenM and CatM transcriptional regulators that normally activate genes for benzoate catabolism. A model is presented in which BenM and CatM prevent pobA expression indirectly during growth on benzoate. These regulators may affect pobA expression by lowering the PcaK-mediated uptake of 4-hydroxybenzoate. Consistent with this model, BenM and CatM bound in vitro to an operator-promoter fragment controlling the expression of several pca genes, including pcaK. These studies provide the first direct evidence of transcriptional cross-regulation between the distinct but analogous branches of the beta-ketoadipate pathway.
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