ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2003
Functional domains for amelogenin revealed by compound genetic defects.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Oligomerization Function of the Native Exon 5 Sequence of Ameloblastin Fused with Calmodulin.ACS omega · 2025Article
- Role of amelogenin phosphorylation in regulating dental enamel formation.Matrix biology : journal of the International Society for Matrix Biology · 2024Article
- Engineering peptide-polymer hybrids for targeted repair and protection of cervical lesions.Frontiers in dental medicine · 2022Article
- Minimal amelogenin domain for enamel formation.JOM (Warrendale, Pa. : 1989) · 2021Article
- Harnessing biomolecules for bioinspired dental biomaterials.Journal of materials chemistry. B · 2020Review
- Ameloblastin Binds to Phospholipid Bilayers via a Helix-Forming Motif within the Sequence Encoded by Exon 5.ACS omega · 2019Article
- DENTAL ENAMEL FORMATION AND IMPLICATIONS FOR ORAL HEALTH AND DISEASE.Physiological reviews · 2017Review
- Preparative SDS PAGE as an Alternative to His-Tag Purification of Recombinant Amelogenin.Frontiers in physiology · 2017Article
- Amyloid-like ribbons of amelogenins in enamel mineralization.Scientific reports · 2016Article
- Interactions of amelogenin with phospholipids.Biopolymers · 2015Article
- Structural adaptation of tooth enamel protein amelogenin in the presence of SDS micelles.Biopolymers · 2014Article
- Localization and quantitative co-localization of enamelin with amelogenin.Journal of structural biology · 2013Article
- Cementomimetics-constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides.International journal of oral science · 2012Article
- Protein-mediated enamel mineralization.Frontiers in bioscience (Landmark edition) · 2012Review
- The role of amelogenin during enamel-crystallite growth and organization in vivo.European journal of oral sciences · 2011Article
- Effect of phosphorylation on the interaction of calcium with leucine-rich amelogenin peptide.European journal of oral sciences · 2011Article
- Leucine-rich amelogenin peptides regulate mineralization in vitro.Journal of dental research · 2011Article
- Potential role of the amelogenin N-terminus in the regulation of calcium phosphate formation in vitro.Cells, tissues, organs · 2011Article
- Synergistic roles of amelogenin and ameloblastin.Journal of dental research · 2009Article
- Biglycan overexpression on tooth enamel formation in transgenic mice.Anatomical record (Hoboken, N.J. : 2007) · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We have previously used the yeast two-hybrid assay and multiple in vitro methodologies to show that amelogenin undergoes self-assembly involving two domains (A and B). Using transgenic animals, we show that unique enamel phenotypes result from disruptions to either the A- or B-domain, supporting the role of amelogenin in influencing enamel structural organization. By crossbreeding, animals bearing two defective amelogenin gene products have a more extreme enamel phenotype than the sum of the defects evident in the individual parental lines. At the nanoscale level, the forming matrix shows alteration in the size of the amelogenin nanospheres. At the mesoscale level of enamel structural hierarchy, 6-week-old enamel exhibits defects in enamel rod organization caused by perturbed organization of the precursor organic matrix. These studies reflect the critical dependency of amelogenin self-assembly to form a highly organized enamel organic matrix, and that amelogenins engineered to be defective in self-assembly produce compound defects in the structural organization of enamel.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.