ArticleBritish journal of cancer2003
A proliferation-dependent bystander effect in primary porcine and human urothelial explants in response to targeted irradiation.
Article in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 108 citations in OpenAlex.
- Radiation-Induced Bystander Effect: Loss of Radioprotective Capacity of Rosmarinic Acid In Vivo and In Vitro.Antioxidants (Basel, Switzerland) · 2021Article
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- Changes in gene expression as one of the key mechanisms involved in radiation-induced bystander effect.Biomedical reports · 2018Review
- Article
- A Mouse Ear Model for Bystander Studies Induced by Microbeam Irradiation.Radiation research · 2015Article
- Radiation-Induced Bystander Response: Mechanism and Clinical Implications.Advances in wound care · 2014Review
- Novel features of radiation-induced bystander signaling in Arabidopsis thaliana demonstrated using root micro-grafting.Plant signaling & behavior · 2012Article
- Emerging role of radiation induced bystander effects: Cell communications and carcinogenesis.Genome integrity · 2010Article
- Investigation of adaptive responses in bystander cells in 3D cultures containing tritium-labeled and unlabeled normal human fibroblasts.Radiation research · 2010Article
- Development of a method for assessing non-targeted radiation damage in an artificial 3D human skin model.International journal of radiation biology · 2010Article
- Bystander effects induced by diffusing mediators after photodynamic stress.Radiation research · 2009Article
- Radiation-induced bystander signalling in cancer therapy.Nature reviews. Cancer · 2009Review
- Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Protective bystander effects simulated with the state-vector model.Dose-response : a publication of International Hormesis Society · 2007Article
- Radiation-induced bystander effects: evidence for an adaptive response to low dose exposures?Dose-response : a publication of International Hormesis Society · 2006Article
- Low-LET-induced radioprotective mechanisms within a stochastic two-stage cancer model.Dose-response : a publication of International Hormesis Society · 2006Article
- Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Genetic and epigenetic features in radiation sensitivity Part I: cell signalling in radiation response.European journal of nuclear medicine and molecular imaging · 2005Review
- An examination of radiation hormesis mechanisms using a multistage carcinogenesis model.Nonlinearity in biology, toxicology, medicine · 2004Article
- Low-dose radiation and genotoxic chemicals can protect against stochastic biological effects.Nonlinearity in biology, toxicology, medicine · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to test whether radiation-induced bystander effects are involved in the response of multicellular systems to targeted irradiation. A primary explant technique was used that reconstructed the in vivo microarchitecture of normal urothelium with proliferating and differentiated cells present. Sections of human and porcine ureter were cultured as explants and irradiated on day 7 when the urothelial outgrowth formed a halo around the tissue fragment. The Gray Cancer Institute charge particle microbeam facility allowed the irradiation of individual cells within the explant outgrowth with a predetermined exact number of (3)He(2+) ions (which have very similar biological effectiveness to alpha-particles). A total of 10 individual cell nuclei were irradiated with 10 (3)He(2+) ions either on the periphery, where proliferating cells are located, or at the centre of the explant outgrowth, which consisted of terminally differentiated cells. Samples were fixed 3 days after irradiation, stained and scored. The fraction of apoptotic and micronucleated cells was measured and a significant bystander-induced damage was observed. Approximately 2000-6000 cells could be damaged by the irradiation of a few cells initially, suggesting a cascade mechanism of cell damage induction. However, the fraction of micronucleated and apoptotic cells did not exceed 1-2% of the total number of the cells within the explant outgrowth. It is concluded that the bystander-induced damage depends on the proliferation status of the cells and can be observed in an in vitro explant model.
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