ArticleJournal of bacteriology2003
Plasmid R16 ArdA protein preferentially targets restriction activity of the type I restriction-modification system EcoKI.
Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Bacterial restriction-modification systems: mechanisms of defense against phage infection.Biophysics reports · 2025Article
- Functional comparison of anti-restriction and anti-methylation activities of ArdA, KlcA, and KlcAFrontiers in cellular and infection microbiology · 2022Article
- Staphylococci on ICE: Overlooked agents of horizontal gene transfer.Mobile genetic elements · 2017Review
- Use of single molecule sequencing for comparative genomics of an environmental and a clinical isolate of Clostridium difficile ribotype 078.BMC genomics · 2016Article
- Type I restriction enzymes and their relatives.Nucleic acids research · 2014Review
- Mutations of the domain forming the dimeric interface of the ArdA protein affect dimerization and antimodification activity but not antirestriction activity.The FEBS journal · 2013Article
- The structure of the KlcA and ArdB proteins reveals a novel fold and antirestriction activity against Type I DNA restriction systems in vivo but not in vitro.Nucleic acids research · 2010Article
- Extensive DNA mimicry by the ArdA anti-restriction protein and its role in the spread of antibiotic resistance.Nucleic acids research · 2009Article
- Tracking EcoKI and DNA fifty years on: a golden story full of surprises.Nucleic acids research · 2003Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ArdA antirestriction protein of the IncB plasmid R16 selectively inhibited the restriction activity of EcoKI, leaving significant levels of modification activity under conditions in which restriction was almost completely prevented. The results are consistent with the hypothesis that ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.
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Registered trials
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