ArticleGenetics2003
Quantitative trait loci responsible for variation in sexually dimorphic traits in Drosophila melanogaster.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 133 citations in OpenAlex.
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- Interplay between sex determination cascade and major signaling pathways during Drosophila eye development: Perspectives for future research.Developmental biology · 2021Review
- Redundant and Cryptic Enhancer Activities of theGenetics · 2019Article
- bric à brac (bab), a central player in the gene regulatory network that mediates thermal plasticity of pigmentation in Drosophila melanogaster.PLoS genetics · 2018Article
- Sex and Genetic Background Influence Superoxide Dismutase (cSOD)-Related Phenotypic Variation inG3 (Bethesda, Md.) · 2017Article
- Regulation of Drosophila Lifespan by bellwether Promoter Alleles.Scientific reports · 2017Article
- Quantifying Abdominal Pigmentation in Drosophila melanogaster.Journal of visualized experiments : JoVE · 2017Article
- The large X-effect on secondary sexual characters and the genetics of variation in sex comb tooth number inEcology and evolution · 2017Article
- Genetic dissection of intraspecific variation in a male-specific sexual trait in Drosophila melanogaster.Heredity · 2016Article
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- The pdm3 Locus Is a Hotspot for Recurrent Evolution of Female-Limited Color Dimorphism in Drosophila.Current biology : CB · 2016Article
- Reconciling Differences in Pool-GWAS Between Populations: A Case Study of Female Abdominal Pigmentation in Drosophila melanogaster.Genetics · 2016Article
- The Genetic Basis of Pigmentation Differences Within and Between Drosophila Species.Current topics in developmental biology · 2016Review
- Genetic Changes to a Transcriptional Silencer Element Confers Phenotypic Diversity within and between Drosophila Species.PLoS genetics · 2015Article
- Genetic Architecture of Abdominal Pigmentation in Drosophila melanogaster.PLoS genetics · 2015Article
- The evolutionary origination and diversification of a dimorphic gene regulatory network through parallel innovations in cis and trans.PLoS genetics · 2015Article
- Article
- Unraveling the Tangled Skein: The Evolution of Transcriptional Regulatory Networks in Development.Annual review of genomics and human genetics · 2015Review
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Authors and funding
5 authors at 4 institutions in 1 country.
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Abstract
To understand the mechanisms of morphological evolution and species divergence, it is essential to elucidate the genetic basis of variation in natural populations. Sexually dimorphic characters, which evolve rapidly both within and among species, present attractive models for addressing these questions. In this report, we map quantitative trait loci (QTL) responsible for variation in sexually dimorphic traits (abdominal pigmentation and the number of ventral abdominal bristles and sex comb teeth) in a natural population of Drosophila melanogaster. To capture the pattern of genetic variation present in the wild, a panel of recombinant inbred lines was created from two heterozygous flies taken directly from nature. High-resolution mapping was made possible by cytological markers at the average density of one per 2 cM. We have used a new Bayesian algorithm that allows QTL mapping based on all markers simultaneously. With this approach, we were able to detect small-effect QTL that were not evident in single-marker analyses. Our results show that at least for some sexually dimorphic traits, a small number of QTL account for the majority of genetic variation. The three strongest QTL account for >60% of variation in the number of ventral abdominal bristles. Strikingly, a single QTL accounts for almost 60% of variation in female abdominal pigmentation. This QTL maps to the chromosomal region that Robertson et al. have found to affect female abdominal pigmentation in other populations of D. melanogaster. Using quantitative complementation tests, we demonstrate that this QTL is allelic to the bric a brac gene, whose expression has previously been shown to correlate with interspecific differences in pigmentation. Multiple bab alleles that confer distinct phenotypes appear to segregate in natural populations at appreciable frequencies, suggesting that intraspecific and interspecific variation in abdominal pigmentation may share a similar genetic basis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.