ArticleGenetics2003
Natural selection for polymorphism in the disease resistance gene Rps2 of Arabidopsis thaliana.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- The molecular evolutionary basis of species formation revisited.Trends in genetics : TIG · 2025Review
- Navigating Host Immunity and Concurrent Ozone Stress: Strain-Resolved Metagenomics Reveals Maintenance of Intraspecific Diversity and Genetic Variation inEvolutionary applications · 2025Article
- Extracellular niche establishment by plant pathogens.Nature reviews. Microbiology · 2024Review
- Phylogenetic analysis of ABCG subfamily proteins in plants: functional clustering and coevolution with ABCGs of pathogens.Physiologia plantarum · 2021Article
- Plant NLR diversity: the known unknowns of pan-NLRomes.The Plant cell · 2021Review
- A Truncated Singleton NLR Causes Hybrid Necrosis in Arabidopsis thaliana.Molecular biology and evolution · 2021Article
- Allele mining unlocks the identification of RYMV resistance genes and alleles in African cultivated rice.BMC plant biology · 2020Article
- Genes Encoding Recognition of theG3 (Bethesda, Md.) · 2020Article
- Evolutionary dynamics and impacts of chromosome regions carrying R-gene clusters in rice.Scientific reports · 2020Article
- Population Genetics of the Highly PolymorphicGenes · 2019Article
- Article
- Drought adaptation ineLife · 2018Article
- Restriction associated DNA-genotyping at multiple spatial scales in Arabidopsis lyrata reveals signatures of pathogen-mediated selection.BMC genomics · 2018Article
- Plastic Transcriptomes Stabilize Immunity to Pathogen Diversity: The Jasmonic Acid and Salicylic Acid Networks within the Arabidopsis/The Plant cell · 2017Article
- Human Management of a Wild Plant Modulates the Evolutionary Dynamics of a Gene Determining Recessive Resistance to Virus Infection.PLoS genetics · 2016Article
- Genetic architecture and pleiotropy shape costs of Rps2-mediated resistance in Arabidopsis thaliana.Nature plants · 2016Article
- Cassava (Manihot esculenta) transcriptome analysis in response to infection by the fungus Colletotrichum gloeosporioides using an oligonucleotide-DNA microarray.Journal of plant research · 2016Article
- Distribution and haplotype diversity of WKS resistance genes in wild emmer wheat natural populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
- Genome-wide detection of intervals of genetic heterogeneity associated with complex traits.Bioinformatics (Oxford, England) · 2015Article
- Impacts of nucleotide fixation during soybean domestication and improvement.BMC plant biology · 2015Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
Pathogen resistance is an ecologically important phenotype increasingly well understood at the molecular genetic level. In this article, we examine levels of avrRpt2-dependent resistance and Rps2 locus DNA sequence variability in a worldwide sample of 27 accessions of Arabidopsis thaliana. The rooted parsimony tree of Rps2 sequences drawn from a diverse set of ecotypes includes a deep bifurcation separating major resistance and susceptibility clades of alleles. We find evidence for selection maintaining these alleles and identify the N-terminal part of the leucine-rich repeat region as a probable target of selection. Additional protein variants are found within the two major clades and correlate well with measurable differences among ecotypes in resistance to the avirulence gene avrRpt2 of the pathogen Pseudomonas syringae. Long-lived polymorphisms have been observed for other resistance genes of A. thaliana; the Rps2 data suggest that the long-term maintenance of phenotypic variation in resistance genes may be a general phenomenon and are consistent with diversifying selection acting in concert with selection to maintain variation.
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