ArticleGenetics2003
The promoter of the heterochromatic Drosophila telomeric retrotransposon, HeT-A, is active when moved into euchromatic locations.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Transcriptional coupling of telomeric retrotransposons with the cell cycle.Science advances · 2025Article
- Mod(mdg4) variants repress telomeric retrotransposon HeT-A by blocking subtelomeric enhancers.Nucleic acids research · 2022Article
- Taming active transposons at Drosophila telomeres: The interconnection between HipHop's roles in capping and transcriptional silencing.PLoS genetics · 2021Article
- Drosophila: Retrotransposons Making up Telomeres.Viruses · 2017Review
- The hnRNP A1 homolog Hrb87F/Hrp36 is important for telomere maintenance in Drosophila melanogaster.Chromosoma · 2016Article
- Article
- Coordination of transposon expression with DNA replication in the targeting of telomeric retrotransposons in Drosophila.The EMBO journal · 2014Article
- The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART.Mobile DNA · 2013Article
- Retrotransposons at Drosophila telomeres: host domestication of a selfish element for the maintenance of genome integrity.Biochimica et biophysica acta · 2012Review
- The chromosomal proteins JIL-1 and Z4/Putzig regulate the telomeric chromatin in Drosophila melanogaster.PLoS genetics · 2012Article
- Mechanism of the piRNA-mediated silencing of Drosophila telomeric retrotransposons.Nucleic acids research · 2011Article
- Role of piRNAs in the Drosophila telomere homeostasis.Mobile genetic elements · 2011Article
- Transcriptional activity of the telomeric retrotransposon HeT-A in Drosophila melanogaster is stimulated as a consequence of subterminal deficiencies at homologous and nonhomologous telomeres.Molecular and cellular biology · 2007Article
- Review
- Genomic organization of the Drosophila telomere retrotransposable elements.Genome research · 2006Article
- Telomere elongation is under the control of the RNAi-based mechanism in the Drosophila germline.Genes & development · 2006Article
- RNA interference has a role in regulating Drosophila telomeres.Genome biology · 2006Review
- Two distinct domains in Drosophila melanogaster telomeres.Genetics · 2005Article
- Article
- Two retrotransposons maintain telomeres in Drosophila.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2005Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila telomeric retrotransposon, HeT-A, is found only in heterochromatin; therefore, its promoter must function in this chromatin environment. Studies of position effect variegation suggest that promoters of heterochromatic genes are very different from euchromatic promoters, but this idea has not been tested with isolated promoter sequences. The HeT-A promoter is the first heterochromatin promoter to be isolated and it is of interest to investigate its activity when removed from telomeric heterochromatin. This promoter was initially characterized by testing reporter constructs in transient transfection of cultured cells, an environment that may approximate its endogenous heterochromatin. We now report P-element-mediated transpositions of these constructs, testing the function of different parts of the putative promoter in euchromatin. Expression of endogenous HeT-A RNA shows marked developmental regulation and accumulates preferentially in replicating diploid tissues. HeT-A promoter constructs are active in all euchromatic locations tested and some display aspects of endogenous HeT-A stage- and cell-type expression programs. The activity of each promoter construct in euchromatic locations is also generally consistent with its activity in the transient transfection tests; a possibly significant exception is one sequence segment that appreciably enhanced activity in transient transfection but repressed promoter activity in euchromatin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.