Evidence map›Paper›PMID 12618379›Full record

ArticleGenome research2003

The development of a highly informative mouse Simple Sequence Length Polymorphism (SSLP) marker set and construction of a mouse family tree using parsimony analysis.

Philip D Witmer, Kimberly F Doheny, Marcia K Adams, Corinne D Boehm, Jane S Dizon, Janet L Goldstein, Tira M Templeton, Ariana M Wheaton, Penny N Dong, Elizabeth W Pugh and 5 more

Abstract read
In one paragraph

Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Frontiers in cell and developmental biology · 2022
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  9. Mouse cell line authentication.Cytotechnology · 2014
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  20. Genetic loci affecting body weight and fatness in a C57BL/6J x PWK/PhJ mouse intercross.Mammalian genome : official journal of the International Mammalian Genome Society · 2007
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Philip D WitmerCenter for Inherited Disease Research (CIDR), Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA. dwitmer@cidr.jhmi.edu
Kimberly F Doheny
Marcia K Adams
Corinne D Boehm
Jane S Dizon
Janet L Goldstein
Tira M Templeton
Ariana M Wheaton
Penny N Dong
Elizabeth W Pugh
Robert L Nussbaum
Kent Hunter
Jennifer A Kelmenson
Lucy B Rowe
Michael J Brownstein

Funding

GENOTYPING FOR LOCATING HUMAN DISEASE GENESN01HG065403 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID L · 1996 to 2000
$1.7M
GENETICS OF COMPLEX TRAITS IN HUMANS AND RODENTSZ01MH002771 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BROWNSTEIN, MICHAEL · 1998 to 2004
–
NHGRI NIH HHS HG00941NHGRI NIH HHS N01 HG065403
6 · The paper itself

Abstract

To identify highly informative markers for a large number of commonly employed murine crosses, we selected a subset of the extant mouse simple sequence length polymorphism (SSLP) marker set for further development. Primer pairs for 314 SSLP markers were designed and typed against 54 inbred mouse strains. We designed new PCR primer sequences for the markers selected for multiplexing using the fluorescent dyes FAM, VIC, NED, and ROX. The number of informative markers for C57BL/6J x DBA/2J is 217, with an average spacing of 6.8 centiMorgans (cM). For all other pairs of strains, the mean number of informative markers per cross is 197.0 (SD 37.8) with a mean distance between markers of 6.8 cM (SD 1.1). To confirm map positions of the 224 markers in our set that are polymorphic between Mus musculus and Mus spretus, we used The Jackson Laboratory (TJL) interspecific backcross mapping panel (TJL BSS); 168 (75%) of these markers had not been previously mapped in this cross by other investigators, adding new information to this community map resource. With this large data set, we sought to reconstruct a phylogenetic history of the laboratory mouse using Wagner parsimony analysis. Our results are largely congruent with the known history of inbred mouse strains.

Indexed as

AllelesAnimalsChromosome MappingGenetic MarkersMiceMice, Inbred AKRMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLMice, Inbred CBAMice, Inbred DBAMice, Inbred NODMice, Inbred NZBMice, Inbred StrainsPhylogenyPolymorphism, GeneticGenetic Markers

Identifiers

PMID12618379
PMCPMC430270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.