ArticleGenome research2003
Gene discovery in the apicomplexa as revealed by EST sequencing and assembly of a comparative gene database.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed.
- Molecular characterization and protective efficacy of silent information regulator 2A from Eimeria tenella.Parasites & vectors · 2016Trial
- Differential contribution of two organelles of endosymbiotic origin to iron-sulfur cluster synthesis and overall fitness in Toxoplasma.PLoS pathogens · 2021Article
- Low genetic diversity and strong immunogenicity within the apical membrane antigen-1 of plasmodium ovale spp. imported from africa to china.Acta tropica · 2020Article
- An update on Sarcocystis neurona infections in animals and equine protozoal myeloencephalitis (EPM).Veterinary parasitology · 2015Review
- Characterization and localization of an Eimeria-specific protein in Eimeria maxima.Parasitology research · 2013Article
- The Eimeria transcript DB: an integrated resource for annotated transcripts of protozoan parasites of the genus Eimeria.Database : the journal of biological databases and curation · 2013Article
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- Characterisation of full-length cDNA sequences provides insights into the Eimeria tenella transcriptome.BMC genomics · 2012Article
- Article
- Identification and characterization of Eimeria tenella apical membrane antigen-1 (AMA1).PloS one · 2012Article
- Expressed sequence tag analysis of the erythrocytic stage of Plasmodium berghei.The Korean journal of parasitology · 2011Article
- RNA-Seq analysis of splicing in Plasmodium falciparum uncovers new splice junctions, alternative splicing and splicing of antisense transcripts.Nucleic acids research · 2011Article
- Screening the Schistosoma mansoni transcriptome for genes differentially expressed in the schistosomulum stage in search for vaccine candidates.Parasitology research · 2011Article
- Article
- A novel multifunctional oligonucleotide microarray for Toxoplasma gondii.BMC genomics · 2010Article
- Article
- Proteomic comparison of four Eimeria tenella life-cycle stages: unsporulated oocyst, sporulated oocyst, sporozoite and second-generation merozoite.Proteomics · 2009Article
- Genetic diversity of Toxoplasma gondii in animals and humans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- Toxoplasma gondii cyclophilin 18-mediated production of nitric oxide induces Bradyzoite conversion in a CCR5-dependent manner.Infection and immunity · 2009Article
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
Large-scale EST sequencing projects for several important parasites within the phylum Apicomplexa were undertaken for the purpose of gene discovery. Included were several parasites of medical importance (Plasmodium falciparum, Toxoplasma gondii) and others of veterinary importance (Eimeria tenella, Sarcocystis neurona, and Neospora caninum). A total of 55192 ESTs, deposited into dbEST/GenBank, were included in the analyses. The resulting sequences have been clustered into nonredundant gene assemblies and deposited into a relational database that supports a variety of sequence and text searches. This database has been used to compare the gene assemblies using BLAST similarity comparisons to the public protein databases to identify putative genes. Of these new entries, approximately 15%-20% represent putative homologs with a conservative cutoff of p < 10(-9), thus identifying many conserved genes that are likely to share common functions with other well-studied organisms. Gene assemblies were also used to identify strain polymorphisms, examine stage-specific expression, and identify gene families. An interesting class of genes that are confined to members of this phylum and not shared by plants, animals, or fungi, was identified. These genes likely mediate the novel biological features of members of the Apicomplexa and hence offer great potential for biological investigation and as possible therapeutic targets.
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Registered trials
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