ArticleGenome research2003
Analysis of primate genomic variation reveals a repeat-driven expansion of the human genome.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 144 citations in OpenAlex.
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- Genomic Variation, Evolvability, and the Paradox of Mental Illness.Frontiers in psychiatry · 2020Article
- Diversity and evolution of the transposable element repertoire in arthropods with particular reference to insects.BMC evolutionary biology · 2019Article
- Casein Gene Cluster in Camelids: Comparative Genome Analysis and New Findings on Haplotype Variability and Physical Mapping.Frontiers in genetics · 2019Article
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- Transposable Element Targeting by piRNAs in Laurasiatherians with Distinct Transposable Element Histories.Genome biology and evolution · 2016Article
- Optimization of next-generation sequencing transcriptome annotation for species lacking sequenced genomes.Molecular ecology resources · 2016Article
- Neutral nuclear variation in Baboons (genus Papio) provides insights into their evolutionary and demographic histories.American journal of physical anthropology · 2014Article
- Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicity.Genome biology · 2014Article
- Rates and patterns of great ape retrotransposition.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Mammalian NUMT insertion is non-random.Nucleic acids research · 2012Article
- Protein interactions with piALU RNA indicates putative participation of retroRNA in the cell cycle, DNA repair and chromatin assembly.Mobile genetic elements · 2012Article
- Comparative analysis of the primate X-inactivation center region and reconstruction of the ancestral primate XIST locus.Genome research · 2011Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
We performed a detailed analysis of both single-nucleotide and large insertion/deletion events based on large-scale comparison of 10.6 Mb of genomic sequence from lemur, baboon, and chimpanzee to human. Using a human genomic reference, optimal global alignments were constructed from large (>50-kb) genomic sequence clones. These alignments were examined for the pattern, frequency, and nature of mutational events. Whereas rates of single-nucleotide substitution remain relatively constant (1-2 x 10(-9) substitutions/site/year), rates of retrotransposition vary radically among different primate lineages. These differences have lead to a 15%-20% expansion of human genome size over the last 50 million years of primate evolution, 90% of it due to new retroposon insertions. Orthologous comparisons with the chimpanzee suggest that the human genome continues to significantly expand due to shifts in retrotransposition activity. Assuming that the primate genome sequence we have sampled is representative, we estimate that human euchromatin has expanded 30 Mb and 550 Mb compared to the primate genomes of chimpanzee and lemur, respectively.
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Registered trials
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