ArticleGenome research2003
Large-scale variation among human and great ape genomes determined by array comparative genomic hybridization.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
67 citing papers in PubMed, 161 citations in OpenAlex.
- Bacterial DNA invasion triggers transposable element proliferation and genome expansion.bioRxiv : the preprint server for biology · 2026Article
- Centromeric transposable elements and epigenetic status drive karyotypic variation in the eastern hoolock gibbon.Cell genomics · 2025Article
- Centromeric transposable elements and epigenetic status drive karyotypic variation in the eastern hoolock gibbon.bioRxiv : the preprint server for biology · 2024Article
- Haplotype-resolved diverse human genomes and integrated analysis of structural variation.Science (New York, N.Y.) · 2021Article
- Correspondence of aCGH and long-read genome assembly for detection of copy number differences: A proof-of-concept with cichlid genomes.PloS one · 2021Article
- Identification of Structural Variation in Chimpanzees Using Optical Mapping and Nanopore Sequencing.Genes · 2020Article
- The Genomic Substrate for Adaptive Radiation: Copy Number Variation across 12 Tribes of African Cichlid Species.Genome biology and evolution · 2019Article
- Article
- Association between Genomic Instability and Evolutionary Chromosomal Rearrangements in Neotropical Primates.Genome biology and evolution · 2018Article
- Comparison of Compression-Based Measures with Application to the Evolution of Primate Genomes.Entropy (Basel, Switzerland) · 2018Article
- Human Accelerated Regions and Other Human-Specific Sequence Variations in the Context of Evolution and Their Relevance for Brain Development.Genome biology and evolution · 2018Review
- Centromere inheritance through the germline.Chromosoma · 2017Review
- The evolution and population diversity of human-specific segmental duplications.Nature ecology & evolution · 2017Article
- Human adaptation and evolution by segmental duplication.Current opinion in genetics & development · 2016Review
- Evaluation of Apis mellifera syriaca Levant region honeybee conservation using comparative genome hybridization.Genetica · 2016Article
- An alignment-free method to find and visualise rearrangements between pairs of DNA sequences.Scientific reports · 2015Article
- Human gene copy number variation and infectious disease.Human genetics · 2014Review
- Compilation of copy number variants identified in phenotypically normal and parous Japanese women.Journal of human genetics · 2014Article
- Global patterns of apparent copy number variation in birds revealed by cross-species comparative genomic hybridization.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2014Article
- Regulatory element copy number differences shape primate expression profiles.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
Large-scale genomic rearrangements are a major force of evolutionary change and the ascertainment of such events between the human and great ape genomes is fundamental to a complete understanding of the genetic history and evolution of our species. Here, we present the results of an evolutionary analysis utilizing array comparative genomic hybridization (array CGH), measuring copy-number gains and losses among these species. Using an array of 2460 human bacterial artificial chromosomes (BACs) (12% of the genome), we identified a total of 63 sites of putative DNA copy-number variation between humans and the great apes (chimpanzee, bonobo, gorilla, and orangutan). Detailed molecular characterization of a subset of these sites confirmed rearrangements ranging from 40 to at least 175 kb in size. Surprisingly, the majority of variant sites differentiating great ape and human genomes were found within interstitial euchromatin. These data suggest that such large-scale events are not restricted solely to subtelomeric or pericentromeric regions, but also occur within genic regions. In addition, 5/9 of the verified variant sites localized to areas of intrachromosomal segmental duplication within the human genome. On the basis of the frequency of duplication in humans, this represents a 14-fold positional bias. In contrast to previous cytogenetic and comparative mapping studies, these results indicate extensive local repatterning of hominoid chromosomes in euchromatic regions through a duplication-driven mechanism of genome evolution.
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