Evidence map›Paper›PMID 12616121›Full record

ArticleAnnals of surgery2003

Prognostic value of postoperative detection of blood circulating tumor cells in patients with colorectal cancer operated on for cure.

Xavier Bessa, Virgínia Piñol, Sergi Castellví-Bel, Elena Piazuelo, Antonio M Lacy, J Ignasi Elizalde, Josep M Piqué, Antoni Castells

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PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgery, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 5 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 5 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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  19. Clinical relevance associated to the analysis of circulating tumour cells in patients with solid tumours.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2009
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xavier BessaDepartment of Gastroenterology, Institut de Malalties Digestives, Hospital Clínic, IDIBAPS, University of Barcelona, Catalonia, Spain.
Virgínia Piñol
Sergi Castellví-Bel
Elena Piazuelo
Antonio M Lacy
J Ignasi Elizalde
Josep M Piqué
Antoni Castells
Hospital Clínic de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess whether postoperative detection of circulating tumor cells in peripheral blood influenced the prognosis of patients with colorectal cancer after radical surgery. SUMMARY BACKGROUND DATA: In a previous study, the authors demonstrated that baseline detection of blood circulating tumor cells does not have prognostic significance in patients with colorectal cancer. However, surgical procedures may increase tumor cell detachment and mobilization.

methodsSixty-six patients with histologically confirmed colorectal cancer operated on for cure were included in this study. Circulating tumor cells were detected by means of reverse transcriptase-polymerase chain reaction targeting to carcinoembryonic antigen messenger RNA in peripheral blood samples obtained 24 hours after surgery. Endpoints of the study were tumor recurrence, overall survival, and cancer-related survival. Univariate (Kaplan-Meier method) and multivariate (Cox regression model) analyses were performed.

resultsAfter a median follow-up of 36 months, 15 patients (23%) had tumor relapse and 14 had died (21%), 8 of them from a cancer-related cause. Cox regression analysis identified lymph node metastases and gender as independent predictors of tumor recurrence and cancer-related survival, whereas overall survival was dependent on the degree of differentiation of the primary tumor. More importantly, the presence of circulating tumor cells after surgery had no prognostic influence on tumor recurrence, overall survival, or cancer-related survival.

conclusionsPostoperative detection of blood circulating tumor cells had no prognostic significance in patients with colorectal cancer operated on for cure.

Indexed as

Neoplastic Cells, CirculatingAgedCarcinoembryonic AntigenCarcinomaColorectal NeoplasmsDisease-Free SurvivalFemaleHumansLymphatic MetastasisMaleMultivariate AnalysisNeoplasm Recurrence, LocalPrognosisRegression AnalysisRisk FactorsSurvival RateCarcinoembryonic Antigen

Identifiers

PMID12616121
PMCPMC1514320
OpenAlexW1965598407

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.