ArticleThe Plant cell2003
Nicotiana benthamiana gp91phox homologs NbrbohA and NbrbohB participate in H2O2 accumulation and resistance to Phytophthora infestans.
Article in The Plant cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 208 papers.
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Who cites it
208 citing papers in PubMed, 608 citations in OpenAlex.
- Calcium-dependent protein kinase signalling in plant immune responses: current status and future prospects.Planta · 2026Review
- SOBIR1 integrates pathogen recognition and hormonal metabolism in Nicotiana tabacum.Plant physiology · 2026Article
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- Conserved 4-coumarate 3-hydroxylase/ascorbate peroxidase bifunctionality coordinates lignin deposition and plant growth in Brachypodium and Populus.Plant physiology · 2026Article
- Detection of Phosphorylated NADPH Oxidase by Antibody During Plant Immune Responses.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Lipid transfer protein VAS inhibits the hypersensitive response via reactive oxygen species signaling in Nicotiana benthamiana.Journal of experimental botany · 2025Article
- A C2H2-type zinc finger protein TaZFP8-5B negatively regulates disease resistance.BMC plant biology · 2024Article
- Comprehensive Genome-Wide Analysis of the Receptor-like Protein Gene Family and Functional Analysis ofPlants (Basel, Switzerland) · 2024Article
- An Isoflavone Synthase Gene inPlants (Basel, Switzerland) · 2024Article
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- Using Transcriptomics to Determine the Mechanism for the Resistance to Fusarium Head Blight of a Wheat-International journal of molecular sciences · 2024Article
- Enhanced stress resilience in potato by deletion of Parakletos.Nature communications · 2024Article
- The Characteristics and Expression Analysis of the Tomato SlRBOH Gene Family under Exogenous Phytohormone Treatments and Abiotic Stresses.International journal of molecular sciences · 2024Article
- Receptor-like cytoplasmic kinases of different subfamilies differentially regulate SOBIR1/BAK1-mediated immune responses in Nicotiana benthamiana.Nature communications · 2024Article
- Engineered dsRNA-protein nanoparticles for effective systemic gene silencing in plants.Horticulture research · 2024Article
- Article
- FlgI Is a Sec-Dependent Effector ofPlants (Basel, Switzerland) · 2024Article
- Systematic analysis of the Rboh gene family in seven gramineous plants and its roles in response to arbuscular mycorrhizal fungi in maize.BMC plant biology · 2023Article
- Phosphatidylinositol-phospholipase C3 negatively regulates the hypersensitive response via complex signaling with MAP kinase, phytohormones, and reactive oxygen species in Nicotiana benthamiana.Journal of experimental botany · 2023Article
- Soybean transporter AAT Rhg1 abundance increases along the nematode migration path and impacts vesiculation and ROS.Plant physiology · 2023Article
148 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Active oxygen species (AOS) are responsible for triggering defense responses in plants. Respiratory burst oxidase homologs (rboh genes) have been implicated in AOS generation. We have isolated two rboh cDNAs, NbrbohA and NbrbohB, from Nicotiana benthamiana leaves. NbrbohA was expressed constitutively at a low level and the transcripts were increased after mechanical stress of control leaf infiltration, whereas NbrbohB was induced specifically by the protein elicitor INF1 from the potato pathogen Phytophthora infestans. We examined the function of the Nbrboh genes in AOS generation and in the hypersensitive response (HR) using virus-induced gene silencing (VIGS). VIGS indicated that both genes are required for H2O2 accumulation and for resistance to Phytophthora. VIGS of Nbrboh genes also led to a reduction and delay of HR cell death caused by INF1. We further demonstrate that the induction of HR-like cell death by overexpression of a constitutively active mutant of a mitogen-activated protein kinase kinase, MEK(DD), is compromised by VIGS of NBRBOHB: We found that MEK(DD) induced NbrbohB but not NBRBOHA: This work provides genetic evidence for the involvement of a mitogen-activated protein kinase cascade in the regulation of rboh genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.