ArticleThe Journal of experimental medicine2003
T cell receptor gene rearrangement lineage analysis reveals clues for the origin of highly restricted antigen-specific repertoires.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Analysis of T cell receptor clonotypes in tumor microenvironment identifies shared cancer-type-specific signatures.Cancer immunology, immunotherapy : CII · 2022Article
- Clonotypic heterogeneity in cutaneous T-cell lymphoma (mycosis fungoides) revealed by comprehensive whole-exome sequencing.Blood advances · 2019Article
- Crossreactive public TCR sequences undergo positive selection in the human thymic repertoire.The Journal of clinical investigation · 2019Article
- Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Clonal conversion of B lymphoid leukemia reveals cross-lineage transfer of malignant states.Genes & development · 2016Article
- Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Unbiased analysis of TCRα/β chains at the single-cell level in human CD8+ T-cell subsets.PloS one · 2012Article
- Paired analysis of TCRα and TCRβ chains at the single-cell level in mice.The Journal of clinical investigation · 2011Article
- Diversity of the CD8+ T cell repertoire elicited against an immunodominant epitope does not depend on the context of infection.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Article
- TCR-MHC docking orientation: natural selection, or thymic selection?Immunologic research · 2008Review
- Reconstitution of paired T cell receptor alpha- and beta-chains from microdissected single cells of human inflammatory tissues.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Multiple T-cell clones specific for the same foreign pMHC ligand can be generated from a single, ancestral TCR-VDJbeta precursor.Immunologic research · 2004Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to ordered, stage-specific T cell receptor (TCR)-beta and -alpha locus gene rearrangements and cell division during T cell development, a given, ancestral TCR-beta locus VDJ rearrangement might be selected into the mature T cell repertoire as a small cohort of "half-sibling" progeny expressing identical TCR-beta chains paired with different TCR-alpha chains. The low frequency of such a cohort relative to the total alphabeta TCR repertoire precludes their direct identification and characterization in normal mice. We considered it possible that positive selection constraints might limit the diversity of TCR-alpha chains selected to pair with beta chains encoded by an ancestral VDJ-beta rearrangement. If so, half-sibling T cells expressing structurally similar, but different TCR-alpha chains might recognize the same foreign antigen. By single cell polymerase chain reaction analysis of antigen-specific TCRs selected during a model anti-tumor response, we were able to identify clusters of T cells sharing identical VDJ-beta rearrangements but expressing different TCR-alpha chains. The amplification of residual DJ-beta rearrangements as clonal markers allowed us to track T cells expressing different TCR-alpha chains back to a common ancestral VDJ-beta rearrangement. Thus, the diversity of TCR-alpha's selected as partners for a given VDJ-beta rearrangement into the mature TCR repertoire may indeed be very limited.
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